子宫内膜癌幸存者的生活质量：斯洛伐克单机构的经验。
Quality of life in endometrial cancer survivors: single institution experience in Slovakia.
机构信息
Gynecology and Obstetrics Department, Faculty Hospital Nitra and Constantine The Philosopher University in Nitra, Spitalska 6, 949 01, Nitra, Slovakia.
出版信息
Health Qual Life Outcomes. 2020 Jul 10;18(1):221. doi: 10.1186/s12955-020-01474-1.
BACKGROUND
To evaluate the association between body mass index (BMI) and quality of life among endometrial cancer survivors.
METHODS
Women diagnosed with endometrioid endometrial cancer at the Slovakian university hospital between January 2010 and December 2018 were identified. Three hundred ninety women diagnosed with endometrial cancer were invited to participate. Quality of life was measured using the EORTC (European Organisation for Reseach and Treatment of Cancer) quality of life questionnaires (QLQ-C30 and QLQ-EN24). Univariate and multiple regression analyses were used to determine associations between BMI and quality-of-life outcome variables. T-test was used to determine differences between groups.
RESULTS
337 (95.2%) women completed the questionnaire. 131 (38.8%) were pre-obese, 111 (32.9%) were class I and II obese and 29 (8.6%) were class III obese. Women with highher BMI experienced poorer physical, emotional and social functioning compared to normal weignt and pre-obese pacients (p < 0.05). Class I-III obese women had significantly more lymphoedema (59% v. 41%, p = 0.048) and dyspnea (73% v. 27%, p = 0.029), and experienced more fatigue (68% v, 32%, p = 0.036) and pain (65% v. 35%, p = 0.041).
CONCLUSIONS
Class I-III obesity was associated with poorer quality of life in endometrial cancer survivors. Increasing BMI was inversely associated with QoL. Pre-obese and obese patients should be informed about greater incidence of pain, fatigue and dyspnea. Lifestyle changes (e.g., dietary interventions, physical activity) might reduce obesity and improve quality of life among endometrial cancer survivors.
背景
评估身体质量指数（BMI）与子宫内膜癌幸存者生活质量之间的关系。
方法
在 2010 年 1 月至 2018 年 12 月期间，在斯洛伐克大学医院诊断为子宫内膜样子宫内膜癌的女性被确定为研究对象。邀请了 390 名被诊断患有子宫内膜癌的女性参加研究。生活质量使用 EORTC（欧洲癌症研究与治疗组织）生活质量问卷（QLQ-C30 和 QLQ-EN24）进行测量。使用单变量和多变量回归分析来确定 BMI 与生活质量结果变量之间的关系。使用 T 检验来确定组之间的差异。
结果
337 名（95.2%）女性完成了问卷。131 名（38.8%）为超重，111 名（32.9%）为 I 类和 II 类肥胖，29 名（8.6%）为 III 类肥胖。与正常体重和超重患者相比，BMI 较高的女性在身体、情绪和社会功能方面表现更差（p<0.05）。I 类-III 类肥胖女性的淋巴水肿（59%对 41%，p=0.048）和呼吸困难（73%对 27%，p=0.029）明显更多，且经历了更多的疲劳（68%对 32%，p=0.036）和疼痛（65%对 35%，p=0.041）。
结论
I 类-III 类肥胖与子宫内膜癌幸存者生活质量较差相关。BMI 增加与 QoL 呈负相关。超重和肥胖患者应被告知疼痛、疲劳和呼吸困难发生率增加。生活方式改变（如饮食干预、体育活动）可能会降低肥胖率，提高子宫内膜癌幸存者的生活质量。
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