吸烟相关肺癌的治疗靶点。
A therapeutic target for smoking-associated lung cancer.
机构信息
Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
出版信息
Sci Transl Med. 2010 Dec 15;2(62):62ps56. doi: 10.1126/scitranslmed.3001942.
PMID:21160076
Abstract
A report in this issue of Science Translational Medicine reveals that amplification of the FGFR1 gene-which encodes fibroblast growth factor receptor 1-is a major oncogenic aberration in squamous cell lung cancer. This genetic variation may represent the first relatively high-frequency therapeutic target of smoking-associated lung cancer.
摘要
本期《科学转化医学》杂志的一篇报道揭示，FGFR1 基因（编码成纤维细胞生长因子受体 1）的扩增是鳞状细胞肺癌的主要致癌异常。这种遗传变异可能代表了与吸烟相关的肺癌的第一个相对高频的治疗靶点。
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