Feierstein Claudia E, Lazarini Françoise, Wagner Sebastien, Gabellec Marie-Madeleine, de Chaumont Fabrice, Olivo-Marin Jean-Christophe, Boussin François D, Lledo Pierre-Marie, Gheusi Gilles
Laboratory for Perception and Memory, Institut Pasteur Paris, France.
Front Behav Neurosci. 2010 Dec 1;4:176. doi: 10.3389/fnbeh.2010.00176. eCollection 2010.
Adult-born neurons arrive to the olfactory bulb (OB) and integrate into the existing circuit throughout life. Despite the prevalence of this phenomenon, its functional impact is still poorly understood. Recent studies point to the importance of newly generated neurons to olfactory learning and memory. Adult neurogenesis is regulated by a variety of factors, notably by instances related to reproductive behavior, such as exposure to mating partners, pregnancy and lactation, and exposure to offspring. To study the contribution of olfactory neurogenesis to maternal behavior and social recognition, here we selectively disrupted OB neurogenesis using focal irradiation of the subventricular zone in adult female mice. We show that reduction of olfactory neurogenesis results in an abnormal social interaction pattern with male, but not female, conspecifics; we suggest that this effect could result from the inability to detect or discriminate male odors and could therefore have implications for the recognition of potential mating partners. Disruption of OB neurogenesis, however, neither impaired maternal-related behaviors, nor did it affect the ability of mothers to discriminate their own progeny from others.
成年新生神经元会抵达嗅球（OB），并在一生中融入现有的神经回路。尽管这种现象很普遍，但其功能影响仍知之甚少。最近的研究指出新生神经元对嗅觉学习和记忆的重要性。成年神经发生受多种因素调节，特别是与生殖行为相关的情况，如接触交配对象、怀孕和哺乳以及接触后代。为了研究嗅觉神经发生对母性行为和社会识别的作用，我们在此通过对成年雌性小鼠脑室下区进行局部照射，选择性地破坏了嗅球神经发生。我们发现，嗅觉神经发生的减少会导致与雄性而非雌性同种个体的社会互动模式异常；我们认为这种影响可能是由于无法检测或区分雄性气味所致，因此可能对识别潜在交配对象有影响。然而，嗅球神经发生的破坏既没有损害与母性相关的行为，也没有影响母亲区分自己后代与其他后代的能力。
