Bovetti Serena, Bonzano Sara, Luzzati Federico, Dati Claudio, De Marchis Silvia, Peretto Paolo
Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin, Italy.
NICO-Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Int J Mol Sci. 2024 Dec 28;26(1):163. doi: 10.3390/ijms26010163.
Over the last three decades, adult neurogenesis in mammals has been a central focus of neurobiological research, providing insights into brain plasticity and function. However, interest in this field has recently waned due to challenges in translating findings into regenerative applications and the ongoing debate about the persistence of this phenomenon in the adult human brain. Despite these hurdles, significant progress has been made in understanding how adult neurogenesis plays a critical role in the adaptation of brain circuits to environmental stimuli regulating key brain functions. This review focuses on the role of olfactory neurogenesis in the brain's response to social reproductive cues in rodents, highlighting its influence on animal behaviors critical for survival. We also address open questions and propose future directions to advance our understanding of the relationship between adult neurogenesis and reproductive function regulation.
在过去三十年中,哺乳动物的成体神经发生一直是神经生物学研究的核心焦点,为深入了解大脑可塑性和功能提供了线索。然而,由于将研究结果转化为再生应用面临挑战,以及关于这一现象在成体人类大脑中是否持续存在的争论不断,该领域的研究兴趣最近有所下降。尽管存在这些障碍,但在理解成体神经发生如何在大脑回路适应调节关键脑功能的环境刺激中发挥关键作用方面已经取得了重大进展。本综述聚焦于嗅觉神经发生在啮齿动物大脑对社会生殖线索的反应中的作用,强调其对动物生存至关重要的行为的影响。我们还探讨了悬而未决的问题,并提出了未来的研究方向,以增进我们对成体神经发生与生殖功能调节之间关系的理解。