Dwivedi Shridhar, Jhamb Rajat
Shridhar Dwivedi, Rajat Jhamb, Department of Medicine/Preventive Cardiology, University College of Medical Sciences, University of Delhi and G.T.B. Hospital, Delhi 110095, India.
World J Cardiol. 2010 Sep 26;2(9):262-9. doi: 10.4330/wjc.v2.i9.262.
Coronary artery disease (CAD) is rapidly increasing in prevalence across the world and particularly in south Asians at a relatively younger age. As atherosclerosis starts in early childhood, the process of risk evaluation must start quite early. The present review addresses the issue of cutaneous markers associated with atherosclerosis, and the strengths and weaknesses of the markers in identifying early coronary atherosclerosis. A diligent search for such clinical markers, namely xanthelasma, xanthoma, arcus juvenilis, acanthosis nigricans, skin tags, ear lobe crease, nicotine stains, premature graying in smokers, hyperpigmented hands in betel quid sellers, central obesity, and signs of peripheral vascular disease may prove to be a rewarding exercise in identifying asymptomatic CAD in high risk individuals.
冠状动脉疾病（CAD）在全球的患病率正在迅速上升，尤其是在相对年轻的南亚人群中。由于动脉粥样硬化始于儿童早期，风险评估过程必须很早就开始。本综述探讨了与动脉粥样硬化相关的皮肤标志物问题，以及这些标志物在识别早期冠状动脉粥样硬化方面的优缺点。认真寻找此类临床标志物，即睑黄瘤、黄瘤、青年环、黑棘皮病、皮赘、耳垂皱褶、尼古丁斑、吸烟者过早白发、嚼槟榔者手部色素沉着、中心性肥胖以及外周血管疾病的体征，可能会成为在高危个体中识别无症状CAD的一项有价值的工作。
