人类朊病毒病的神经影像学：雾中探寻。
Neuroimaging in human prion disease: Searching in the mist.
作者信息
Ioannides Panayotis, Karacostas Dimitris
机构信息
Panayotis Ioannides, Dimitris Karacostas, Β' Department of Neurology, AHEPA University Hospital, Thessaloniki 54636, Greece.
出版信息
World J Radiol. 2009 Dec 31;1(1):45-9. doi: 10.4329/wjr.v1.i1.45.
Human prion disease is a rare, uniformly fatal neurodegenerative disorder.Its precise pathogenesis is obscure. The clinical profile of the disease differs among its various forms. There are no definitive diagnostic tests (except for brain biopsy) or proven treatment. To increase the clinical diagnostic sensitivity and specificity, three laboratory tests, including electroencephalogram, cerebrospinal fluid testing for 14-3-3 protein, and magnetic resonance imaging, are currently used. Additionally, proton magnetic resonance spectroscopy, positron emission tomography and single photon emission computed tomography can provide interesting and novel results in the research of human prion disease.
人类朊病毒病是一种罕见的、无一例外会致命的神经退行性疾病。其确切发病机制尚不清楚。该疾病的临床特征在不同形式之间有所差异。目前尚无明确的诊断测试（脑活检除外）或经证实的治疗方法。为提高临床诊断的敏感性和特异性，目前使用三种实验室检测方法，包括脑电图、脑脊液14-3-3蛋白检测和磁共振成像。此外，质子磁共振波谱、正电子发射断层扫描和单光子发射计算机断层扫描在人类朊病毒病的研究中可提供有趣且新颖的结果。
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