Singh K, Viegas O A, Ratnam S S
Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Adv Contracept. 1990 Mar;6(1):11-21. doi: 10.1007/BF01849483.
In a longitudinal study involving 100 Singaporean women, the effect of NorplantR on metabolic function was evaluated. With respect to liver function, the results indicate possible hepatocellular dysfunction as evidenced by a significant rise in serum bilirubin and a significant fall in total proteins and globulin during the period under review. As regards lipid metabolism, total triglycerides and total cholesterol still remained significantly decreased at the end of the three years. The LDL, which was significantly decreased in the first year, increased during the subsequent two years to its preinsertion value at the end of three years. The HDL-cholesterol levels continued to decrease in the second and third year after a significant increase in the first year. Despite this, the HDL cholesterol/total cholesterol-HDL cholesterol remained above 0.200. As we have not incorporated a simultaneous non-pill treated control group, the observed changes in lipoprotein lipids could be attributed to extraneous factors such as diet, exercise, or other environmental changes. Nevertheless, the findings at the end of three years, though speculative, still appear to indicate Norplant use to be not directly contributory to cardiovascular risk. The use of Norplant was not associated with any significant effects on carbohydrate metabolism after three years of use.
在一项涉及100名新加坡女性的纵向研究中，评估了NorplantR对代谢功能的影响。关于肝功能，结果表明可能存在肝细胞功能障碍，在所研究期间血清胆红素显著升高以及总蛋白和球蛋白显著下降证明了这一点。至于脂质代谢，三年结束时总甘油三酯和总胆固醇仍显著降低。低密度脂蛋白在第一年显著降低，在随后两年中升高，到三年结束时恢复到植入前的值。高密度脂蛋白胆固醇水平在第一年显著升高后，在第二年和第三年持续下降。尽管如此，高密度脂蛋白胆固醇/总胆固醇-高密度脂蛋白胆固醇仍保持在0.200以上。由于我们没有纳入同时接受非避孕药治疗的对照组，观察到的脂蛋白脂质变化可能归因于饮食、运动或其他环境变化等外部因素。然而，三年结束时的研究结果虽然具有推测性，但似乎仍表明使用Norplant不会直接导致心血管风险。使用Norplant三年后对碳水化合物代谢没有任何显著影响。
