Singh K, Viegas O A, Liew D, Singh P, Ratnam S S
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Contraception. 1989 Feb;39(2):147-54. doi: 10.1016/s0010-7824(89)80003-4.
In this longitudinal study involving 100 Singaporean acceptors, the effects of Norplant-2 rods on metabolic function was evaluated. The mean serum bilirubin during the second year remained significantly raised from its preinsertion value (p less than 0.001). Furthermore the total proteins and globulin were still significantly decreased (p less than 0.001). Thus with respect to liver function, the results still indicate possible dysfunction at the end of two years. As regards lipid metabolism, the serum triglycerides, total cholesterol and LDL-cholesterol still remained significantly decreased at the end of two years when compared to preinsertion values. The HDL-cholesterol levels which showed no significant change during the first year of use decreased significantly during the second year of use. As a result the HDL-cholesterol/Total cholesterol - HDL-cholesterol decreased significantly and was 12.0% lower than the pre-insertion ratio (p less than 0.01). Similarly the LDL-cholesterol/HDL-cholesterol increased during the second year of use and was 2.6% higher than its preinsertion ratio. However, this increase was still not statistically significant. As we have not incorporated a simultaneous non-steroid treated control group, the observed changes in lipid metabolism could be attributed to extraneous factors such as diet, exercise or other environmental changes. Nevertheless, the findings at the end of two years, though speculative, still indicate Norplant-2 use to be non-contributory to cardiovascular risk in this population. The use of Norplant-2 was not associated with any significant effect on glucose tolerance after two years of use.
在这项涉及100名新加坡接受者的纵向研究中，评估了皮下埋植避孕剂Ⅱ型（Norplant-2）棒对代谢功能的影响。第二年的平均血清胆红素仍显著高于植入前水平（p<0.001）。此外，总蛋白和球蛋白仍显著降低（p<0.001）。因此，就肝功能而言，结果仍表明在两年结束时可能存在功能障碍。关于脂质代谢，与植入前值相比，两年结束时血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇仍显著降低。高密度脂蛋白胆固醇水平在使用的第一年没有显著变化，但在使用的第二年显著下降。结果，高密度脂蛋白胆固醇/总胆固醇-高密度脂蛋白胆固醇显著降低，比植入前的比率低12.0%（p<0.01）。同样，低密度脂蛋白胆固醇/高密度脂蛋白胆固醇在使用的第二年有所增加，比植入前的比率高2.6%。然而，这种增加在统计学上仍不显著。由于我们没有纳入同时接受非甾体治疗的对照组，观察到的脂质代谢变化可能归因于饮食、运动或其他环境变化等外部因素。尽管如此，两年结束时的研究结果虽然具有推测性，但仍表明在该人群中使用皮下埋植避孕剂Ⅱ型（Norplant-2）对心血管风险没有影响。使用皮下埋植避孕剂Ⅱ型（Norplant-2）两年后对葡萄糖耐量没有任何显著影响。
