Smetnik V P, Fanchenko N D, Tkachenko N M, Kuznetsov S Iu
Akush Ginekol (Mosk). 1990 Apr(4):32-5.
The study has been done in 30 women with the resistant ovary syndrome diagnosed by laparoscopy, laparotomy and histologic examination of ovarian biopsy samples. Genetic study identified the feminine phenotype and genotype (46,XX). Estradiol levels corresponded to those seen in the follicular menstrual phase, prolactin levels were normal, and gonadotropin levels were above basal values and were several fold above the ovulatory peak, when tested with luteinizing hormone-releasing factor in 7 patients and after estrogen challenge in 5 patients. The tests indicated an adequate adenohypophyseal response and intact feedback mechanisms between the hypothalamic pituitary system and gonadal steroids, as confirmed by electroencephalography.
该研究针对30名经腹腔镜检查、剖腹手术及卵巢活检样本组织学检查确诊为抵抗性卵巢综合征的女性进行。基因研究确定了女性表型和基因型（46,XX）。雌二醇水平与卵泡期月经时的水平相符，催乳素水平正常，促性腺激素水平高于基础值，在7名患者中用促黄体生成素释放因子进行检测时以及在5名患者中进行雌激素激发后，促性腺激素水平比排卵峰值高出几倍。这些检测表明腺垂体反应正常，下丘脑-垂体系统与性腺类固醇之间的反馈机制完整，脑电图检查也证实了这一点。
