肝癌中的蛋白酶及其抑制剂
Proteinases and their inhibitors in liver cancer.
作者信息
Puxbaum Verena, Mach Lukas
机构信息
Verena Puxbaum, Lukas Mach, Department of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, Vienna A-1190, Austria.
出版信息
World J Hepatol. 2009 Oct 31;1(1):28-34. doi: 10.4254/wjh.v1.i1.28.
Abstract
Proteinases are known to be involved in many cancer-related processes, particularly in the breakdown of extracellular matrix barriers in the course of tumor invasion and metastasis. In this review we summarize the current knowledge about the role of the most important matrix-degrading proteinases (cathepsins, matrix metalloproteinases, plasmin/plasminogen activators) and their respective inhibitors in liver cancer progression and metastasis.
摘要
已知蛋白酶参与许多与癌症相关的过程，尤其是在肿瘤侵袭和转移过程中细胞外基质屏障的破坏。在本综述中，我们总结了目前关于最重要的基质降解蛋白酶（组织蛋白酶、基质金属蛋白酶、纤溶酶/纤溶酶原激活剂）及其各自的抑制剂在肝癌进展和转移中的作用的知识。
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