Institute of Developmental Biology, Cologne Biocenter, University of Cologne, Zuelpicher Strasse 47b, 50674 Cologne, Germany.
Plant Mol Biol. 2011 Feb;75(3):223-36. doi: 10.1007/s11103-010-9721-5. Epub 2010 Dec 15.
DORNRÖSCHEN (DRN) and DORNRÖSCHEN-LIKE (DRNL) encode AP2-domain transcription factors, which act redundantly in cotyledon organogenesis. A more detailed genetic study now integrates DRN and DRNL into the CUP-SHAPED COTYLEDON (CUC) regulatory network and places DRN and DRNL differentially within the auxin signalling network: DRNL function overlaps with that of PIN-FORMED1, and DRN with PINOID. DRN and DRNL act cell-autonomously and are co-expressed in the early globular embryo, whereas expression patterns diverge during later stages of embryogeny. Both genes synergize to provide essential patterning information in the apical embryo domain, to establish correct CUC, SHOOTMERISTEMLESS and WUSCHEL expression domains, which relates to the patterning of SAM anlagen to a central apical position to create two planes of bilateral symmetry in wild type Arabidopsis thaliana embryos.
DRN 和 DRNL 编码 AP2 结构域转录因子，在子叶器官发生中起冗余作用。更详细的遗传研究现在将 DRN 和 DRNL 整合到 CUP-SHAPED COTYLEDON（CUC）调控网络中，并将 DRN 和 DRNL 在生长素信号网络中进行差异化定位：DRNL 功能与 PIN-FORMED1 重叠，而 DRN 与 PINOID 重叠。DRN 和 DRNL 自主发挥作用，在早期球形胚胎中共同表达，而在胚胎发生的后期阶段表达模式出现分歧。这两个基因协同作用，为顶端胚胎区域提供必需的模式信息，以建立正确的 CUC、SHOOTMERISTEMLESS 和 WUSCHEL 表达区域，这与 SAM 原基的模式形成有关，以中央顶端位置创建两个平面的双侧对称性在野生型拟南芥胚胎中。
