2nd Medical Department, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030 Vienna, Austria.
Ir J Med Sci. 2011 Sep;180(3):667-72. doi: 10.1007/s11845-010-0655-3. Epub 2010 Dec 14.
The prevalence of coronary pathologic findings in patients with left ventricular hypertrabeculation/noncompaction (LVHT) is unknown. The study in a cohort of consecutive LVHT patients aimed to assess how often coronary angiography (CA) had been performed, if clinical findings and prognosis differed between patients with and without CA, how often pathologic findings of the coronary arteries were found, and if there were differences between LVHT patients with and without coronary pathologic findings.
Between 1995-2007 LVHT was diagnosed in 113 patients (mean age 53 years, 29% females, 67% neuromuscular disorders). CA had been performed in 52. Patients with CA had more exertional dyspnoea (79 vs. 61%, p < 0.05), angina pectoris (42 vs. 10%, p < 0.001), hypertension (44 vs. 25%, p < 0.05) and larger left ventricles (66 vs. 60 mm, p < 0.001) than patients without. No anomalously originating coronary arteries were found. Patients with coronary arteriosclerosis (n = 8) had more right-bundle-branch block than patients without (25 vs. 0%, p < 0.05). Mortality was 5.8% per year and did neither differ between patients with and without CA nor with and without coronary arteriosclerosis.
Coronary arteriosclerosis is rarely associated with LVHT and does not seem to affect prognosis.
左心室心肌肥厚/非致密化（LVHT）患者的冠状动脉病理发现的流行率尚不清楚。本研究对连续 LVHT 患者队列进行评估，旨在评估冠状动脉造影（CA）的实施频率，如果有或没有 CA 的患者之间的临床发现和预后是否不同，冠状动脉的病理发现有多频繁，以及 LVHT 患者与无冠状动脉病理发现的患者之间是否存在差异。
1995-2007 年期间，诊断出 113 例 LVHT 患者（平均年龄 53 岁，29%为女性，67%为神经肌肉疾病）。52 例患者进行了 CA。有 CA 的患者更易出现运动性呼吸困难（79%比 61%，p<0.05）、心绞痛（42%比 10%，p<0.001）、高血压（44%比 25%，p<0.05）和更大的左心室（66 毫米比 60 毫米，p<0.001）。未发现异常起源的冠状动脉。冠状动脉粥样硬化患者（n=8）比无冠状动脉粥样硬化患者更容易出现右束支传导阻滞（25%比 0%，p<0.05）。死亡率为每年 5.8%，在有或没有 CA 的患者之间以及在有或没有冠状动脉粥样硬化的患者之间没有差异。
冠状动脉粥样硬化很少与 LVHT 相关，似乎不会影响预后。
