Löwer J
Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen (Hessen), Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010 Dec;53(12):1238-41. doi: 10.1007/s00103-010-1159-z.
Pandemic influenza vaccines have to fulfill specific requirements. In contrast to seasonal influenza vaccines, they have to be effective even in an immunologically naïve population. In addition, they should be available in a relatively short period of time and should be produced at an unprecedented speed in huge amounts. For this reason, they need a specific design which has to be different from that of seasonal vaccines. With the given technological possibilities, antigen-sparing adjuvanted vaccines most closely fulfill the requirements of an ideal pandemic vaccine.
大流行性流感疫苗必须满足特定要求。与季节性流感疫苗不同，它们即使在免疫原初人群中也必须有效。此外，它们应在相对较短的时间内可用，并且应以前所未有的速度大量生产。因此，它们需要一种与季节性疫苗不同的特定设计。鉴于现有的技术可能性，抗原节约型佐剂疫苗最接近理想大流行疫苗的要求。
