At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop.
作者信息
Kaluz Stefan, Van Meir Erwin G
机构信息
Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
出版信息
J Mol Med (Berl). 2011 Feb;89(2):91-4. doi: 10.1007/s00109-010-0706-2.
Abstract
摘要
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本文引用的文献
1
Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma.Ras 调节白介素-1β诱导的脑胶质瘤中 HIF-1α 的转录活性。
J Mol Med (Berl). 2011 Feb;89(2):123-36. doi: 10.1007/s00109-010-0683-5. Epub 2010 Sep 24.
2
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.核因子-κB通过对缺氧诱导因子-1α的转录调控将天然免疫与缺氧反应联系起来。
Nature. 2008 Jun 5;453(7196):807-11. doi: 10.1038/nature06905. Epub 2008 Apr 23.
3
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.脯氨酰羟化酶-1负向调节IκB激酶-β，这为低氧诱导的核因子κB活性提供了见解。
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18154-9. doi: 10.1073/pnas.0602235103. Epub 2006 Nov 17.
4
Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures.缺氧诱导因子-1（HIF-1）介导星形胶质细胞培养物中白细胞介素-1β（IL-1β）转录激活的证据。
J Neuroimmunol. 2006 May;174(1-2):63-73. doi: 10.1016/j.jneuroim.2006.01.014. Epub 2006 Feb 28.
5
Hypoxia inducible factor-1: a novel target for cancer therapy.缺氧诱导因子-1：癌症治疗的新靶点。
Anticancer Drugs. 2005 Oct;16(9):901-9. doi: 10.1097/01.cad.0000180116.85912.69.
6
Targeting HIF-1 for cancer therapy.以缺氧诱导因子-1为靶点进行癌症治疗。
Nat Rev Cancer. 2003 Oct;3(10):721-32. doi: 10.1038/nrc1187.
7
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.白细胞介素-1β通过核因子κB/环氧化酶-2途径介导缺氧诱导因子-1α的上调，表明缺氧诱导因子-1是炎症与肿瘤发生之间的关键环节。
FASEB J. 2003 Nov;17(14):2115-7. doi: 10.1096/fj.03-0329fje. Epub 2003 Sep 4.
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Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation.星形细胞瘤的遗传和生物学进展及其与血管生成失调的关系。
Adv Anat Pathol. 2002 Jan;9(1):24-36. doi: 10.1097/00125480-200201000-00004.
9
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.脯氨酸羟化作用使HIFα靶向VHL介导的降解：对氧感知的影响
Science. 2001 Apr 20;292(5516):464-8. doi: 10.1126/science.1059817. Epub 2001 Apr 5.
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