Rabino Massa E, Scaroina F, Cavallari L, Amprimo M C, Zola F, Bonetti G, Ricco G
Dip. Biologia Animale, Università di Torino.
Boll Soc Ital Biol Sper. 1990 Mar;66(3):223-30.
Functional parameters of the whole blood oxygen loading from 66 anemic subjects, compared with those from 66 normal adult of both sexes display the following behaviour: a) Adult males and females differ for p50 values, which are higher in females because of their lower Hb level. This difference is already well known and appears to be statistically significant. b) The same difference is amplified in anemic subjects, where also pH lowering contributes to the right-shift of p50. c) The inverse relationship between p50 and DPG values differs if analysed at the actual pHs, at pH corrected at 7.4, or extrapolated from Bohr effect. In fact, the three relative plots do not parallel, and their most significant intersects drop around 0.8-0.9 value of DPG, and 26-27 torr of p50, i.e. within normal limits.
66名贫血受试者全血氧负荷的功能参数与66名正常成年男女的参数相比，呈现出以下情况：a) 成年男性和女性的p50值存在差异，由于女性血红蛋白水平较低，其p50值较高。这种差异早已为人所知，且似乎具有统计学意义。b) 这种差异在贫血受试者中被放大，其中pH值降低也导致p50右移。c) 如果在实际pH值、校正至7.4的pH值或从玻尔效应外推的情况下分析，p50与DPG值之间的反比关系会有所不同。实际上，这三个相关图并不平行，它们最显著的交点落在DPG值约0.8 - 0.9以及p50为26 - 27托时，即在正常范围内。
