Tosetti F, Fabris C, Oneglia C, Pich P G, Bertero M F, Rabino-Massa E, Marchisio U, Burzio P, Ricco G
Boll Soc Ital Biol Sper. 1985 Jan 30;61(1):99-106.
The cord blood from 82 normal newborns (48 males and 34 females) has been extensively investigated, to check p50, cooperativity and related parameters. The most important results are the following: Neonatal p50 is slightly above 20 torr, in good agreement with the literature data, but this value refers to the p50 "CO-free" (T50); otherwise, the original p50 is slightly less than 22 torr, a value which is not indicative enough, because neonatal blood contains a consistent excess of Hb-CO. Either this CO-excess and the low p50 value seem to be mainly depending on the low binding capacity of Hb-F with DPG, even if further studies are still necessary at regard. The empirical factor correcting adult p50 to T50 is -0.27, a value which must be increased to -0.36 for neonatal blood. Multiple gas analyses of the samples indicate that oxygen transport is a very complicate equilibrium involving pH, CO2, bicarbonate balance and other factors. A complete statistical analysis of the data has been carried out and the main result indicates that oxygen assumption favours CO2 releasing and vice versa, a phenomenon already well known and globally called "Bohr effect".
对82名正常新生儿（48名男性和34名女性）的脐带血进行了广泛研究，以检查P50、协同性及相关参数。最重要的结果如下：新生儿的P50略高于20托，与文献数据相符，但该值指的是“无CO”时的P50（T50）；否则，原始P50略低于22托，该值指示性不足，因为新生儿血液中含有大量过量的Hb-CO。即使在这方面仍需进一步研究，但这种CO过量和低P50值似乎主要取决于Hb-F与DPG的低结合能力。将成人P50校正为T50的经验因子为-0.27，对于新生儿血液，该值必须增至-0.36。对样本进行的多次气体分析表明，氧运输是一个非常复杂的平衡过程，涉及pH值、二氧化碳、碳酸氢盐平衡及其他因素。已对数据进行了完整的统计分析，主要结果表明，氧摄取有利于二氧化碳释放，反之亦然，这一现象早已为人所知，统称为“波尔效应”。
