Ueberreiter K, von Finckenstein J G, Cromme F, Herold C, Tanzella U, Vogt P M
Asklepios Klinik Birkenwerder, Abteilung für Plastische und Ästhetische Chirurgie, Hubertusstraße 12– 22, Birkenwerder.
Handchir Mikrochir Plast Chir. 2010 Dec;42(6):379-85. doi: 10.1055/s-0030-1267913. Epub 2010 Dec 15.
After numerous experiments with free-fat transfer since 1893 , many promising methods and results of large-volume fat grafts have been published recently . A common disadvantage was the time of the procedure and a lack of proof of efficiency. In 2007 we developed the BEAULI™ method (Berlin autologous lipotransplantation), a new and reliable procedure to collect larger amounts of transplantable fatty tissue. It was evaluated in a prospective clinical study with 85 patients in 2 centres in Germany, the overall number of transplantations amounting to 216 treated breasts. Indications were general lack of breast volume, either genuine or acquired in the course of surgical procedures. The fat was harvested with the BEAULI™ method, which consists in general of the harvest of very small fat particles by means of water-assisted liposuction (Bodyjet®, Humanmed Ag, Germany) and reinjection of the fat after separation from superfluous water by means of the Lipocollector®. All procedures were performed in a standardised pattern, measurements were taken preoperatively, at day 1 postop, after 1 week, 4 weeks, 3 months, 6 months and then to be continued yearly. An MRI of the breasts was taken preop and 6 months postoperatively, the longest follow-up is 30 months. Average operation time was 1.5 h. In every case a definite increase of volume of the fatty layer in the treated areas was observed. We saw no macroscopic oily cysts, in two cases there were 3 months after the operation some palpable subcutaneous nodules which proved to be granulomas. The volume control of 35 aesthetic patients by means of BrainLab™ Software and MRI could verify a permanent take rate of 76±11% of the grafted fat. In aesthetic patients generally 2 (80%) fat-grafting procedures with an average gain in volume of ½ bra cup size or 100-150 ml) per procedure were required. After implant removal, satisfaction was usually reached after only a single procedure, for complete reconstruction after cancer surgery 4-5 grafting sessions were necessary. An extension of the skin envelope as well as improvement of existing scars were observed.
自1893年以来，在进行了无数次游离脂肪移植实验后，近期已发表了许多关于大量脂肪移植的有前景的方法和结果。一个常见的缺点是手术时间长且缺乏有效性的证据。2007年，我们开发了BEAULI™方法（柏林自体脂肪移植术），这是一种全新且可靠的方法，用于收集大量可移植的脂肪组织。该方法在德国两个中心对85名患者进行的一项前瞻性临床研究中进行了评估，总共对216个乳房进行了移植治疗。适应症为乳房普遍体积不足，包括先天性或手术过程中获得性的。脂肪采用BEAULI™方法采集，该方法一般包括通过水辅助吸脂术（Bodyjet®，德国Humanmed Ag公司）采集非常小的脂肪颗粒，并通过Lipocollector®将脂肪与多余水分分离后再注射。所有手术均按照标准化模式进行，术前、术后第1天、1周、4周、3个月、6个月进行测量，之后每年继续测量。术前和术后6个月进行乳房MRI检查，最长随访时间为30个月。平均手术时间为1.5小时。在每种情况下，均观察到治疗区域脂肪层体积有明确增加。我们未发现肉眼可见的油性囊肿，有两例在术后3个月出现了一些可触及的皮下结节，经证实为肉芽肿。通过BrainLab™软件和MRI对35名美容患者进行的体积控制能够证实移植脂肪的永久留存率为76±11%。在美容患者中，一般需要进行2次（80%）脂肪移植手术，每次手术平均体积增加½罩杯大小或100 - 150毫升。取出植入物后，通常仅需进行一次手术就能达到满意效果，对于癌症手术后的完全重建则需要4 - 5次移植手术。观察到皮肤包膜有扩展以及现有瘢痕有所改善。
