Department No. 16, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
JAMA Facial Plast Surg. 2018 May 1;20(3):222-229. doi: 10.1001/jamafacial.2017.2002.
Autologous fat grafting has revolutionized the field of facial soft-tissue augmentation, despite a lack of standardization. Objective data are needed to arrive at consensus regarding the best technique for optimal volume retention.
To compare 3 fat-processing techniques with 3-dimensional (3-D) technology to explore the optimal fat-processing technique for improving the volume retention of grafted fat.
DESIGN, SETTING, AND PARTICIPANTS: From September 2015 to December 2016, patients with facial asymmetry were treated by initial facial fat grafting at the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Sixty-three patients (21 per group) were randomized to 1 of 3 fat-processing techniques: sedimentation, centrifugation, and cotton pad filtration. Patients underwent 3-D scanning preoperatively and at 1, 3, 6, and 12 months postoperatively. Patients who did not complete preoperative or postoperative follow-up and 3-D imaging were excluded from the analysis.
Autologous fat grafting to correct facial asymmetry.
The percentage volume maintenance of each fat-processing technique was measured with 3-D software and analyzed with variance analysis.
Of the 63 randomized patients, 30 (7 men, 23 women; mean [SD] age at surgery, 22.2 [8.0] years) completed follow-up. The mean (SD) percentage volume maintenance of the 3 groups at 1, 3, 6, and 12 months postoperatively was, respectively, 49% (4%), 45% (3%), 43% (3%), and 41% (3%) for the cotton pad filtration group; 41% (3%), 38% (4%), 36% (4%), and 34% (3%) for the centrifugation group; and 37% (4%), 34% (4%), 31% (3%), and 31% (3%) for sedimentation group. The variance analysis showed that the cotton pad filtration group demonstrated a statistically significant higher percentage volume maintenance in comparison with the centrifugation and sedimentation groups.
The use of 3-D technology provides an objective and accurate way to evaluate different fat-processing techniques. Autologous fat processed by cotton pad filtration had a significant higher volume retention than did that processed by centrifugation and sedimentation technique.
chictr.org.cn Identifier: ChiCTR-IOR-14005599.
尽管自体脂肪移植在面部软组织填充领域具有革命性意义，但它缺乏标准化。需要客观的数据来达成共识，以找到最佳的技术来实现最佳的体积保留。
本研究通过 3 维（3-D）技术比较 3 种脂肪处理技术，以探索最佳的脂肪处理技术，提高移植脂肪的体积保留率。
设计、地点和参与者：本研究纳入 2015 年 9 月至 2016 年 12 月在中国医学科学院整形外科医院接受初次面部脂肪移植治疗的面部不对称患者。63 例患者（每组 21 例）随机分为 3 种脂肪处理技术组：沉降法、离心法和棉垫过滤法。患者术前和术后 1、3、6 和 12 个月进行 3-D 扫描。未完成术前或术后随访和 3-D 成像的患者被排除在分析之外。
自体脂肪移植矫正面部不对称。
采用 3-D 软件测量每种脂肪处理技术的体积维持百分比，并进行方差分析。
在随机的 63 例患者中，30 例（7 例男性，23 例女性；手术时的平均[标准差]年龄，22.2[8.0]岁）完成了随访。术后 1、3、6 和 12 个月，3 组的平均（标准差）体积维持百分比分别为棉垫过滤组 49%（4%）、45%（3%）、43%（3%）和 41%（3%）；离心组 41%（3%）、38%（4%）、36%（4%）和 34%（3%）；沉降组 37%（4%）、34%（4%）、31%（3%）和 31%（3%）。方差分析显示，与离心组和沉降组相比，棉垫过滤组的体积维持百分比具有统计学意义上的显著优势。
使用 3-D 技术提供了一种客观、准确的方法来评估不同的脂肪处理技术。与离心和沉降技术相比，经棉垫过滤处理的自体脂肪具有更高的体积保留率。
chictr.org.cn 标识符：ChiCTR-IOR-14005599。
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