International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany.
Diabetes, Endocrinology and Metabolism Section, Department of Internal Medicine I, St. Josef Hospital, Ruhr University Bochum, NRW, Gudrunstr. 56, 44791 Bochum, Germany.
Int J Mol Sci. 2022 Dec 3;23(23):15250. doi: 10.3390/ijms232315250.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA criteria. Systematic research was carried out using keywords. Subsequently, the data were analyzed based on the clinical response and other relevant information. The main focus of our systematic review was on HS manifestation, exacerbation, sex hormones, antiandrogen therapy, thyroid function, polycystic ovary syndrome, insulin resistance, and adipokines. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients. However, further studies are needed to better understand the hormonal relationship in HS.
化脓性汗腺炎（HS）是一种表现为体腔部位炎症的慢性炎症性疾病。在一项系统综述中，将介绍激素在 HS 中的作用，以更好地理解 HS 的发病机制。该综述基于 PRISMA 标准。使用关键词进行系统研究。随后，根据临床反应和其他相关信息对数据进行分析。我们的系统综述主要关注 HS 的表现、加重、性激素、抗雄激素治疗、甲状腺功能、多囊卵巢综合征、胰岛素抵抗和脂肪因子。在 HS 中，似乎存在一种失调的脂肪因子释放，向促炎脂肪因子转变。无论 BMI、年龄和性别如何，HS 患者的胰岛素抵抗比健康患者更为常见。HS 患者的胰岛素抵抗导致进一步的心血管疾病。胰岛素抵抗的机制和脂肪因子的作用应在未来的研究中进行调查，以更好地提供 HS 的发病机制。雄激素的作用在某些特定的女性患者亚群中似乎很重要。抗雄激素治疗对某些患者可能有用。然而，需要进一步的研究来更好地理解 HS 中的激素关系。
