Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
Int J Biol Markers. 2010 Oct-Dec;25(4):195-9.
To analyze the difference in the distribution of an insulin growth factor-1 (IGF-1) polymorphism (-2995 C/A) between young and old colorectal cancer (CRC) patients.
Information from 950 CRC patients undergoing surgery at the Taipei Veterans General Hospital between 2000 and 2005 was collected. The IGF-1 polymorphism was analyzed in patients in extreme age ranges at the time of CRC onset (i.e., under the 20th and above the 80th percentiles, respectively). Associations between clinicopathological variables and the IGF-1 polymorphism were analyzed.
Young CRC patients had a higher frequency of advanced disease (58.7%) and mucinous adenocarcinoma (20%) than old CRC patients. Among old CRC patients, the frequency of the AA genotype of IGF-1 was 12.7% (24/189), which was significantly higher than in young patients (4.2%). Other clinicopathological factors including tumor location, differentiation, lymphovascular invasion, and TNM stage were not associated with the AA genotype of IGF-1. Mucinous differentiation (but not the other clinicopathological factors) was significantly associated with the CA/AA genotype of IGF-1 (39/195).
Older patients had a higher frequency of the AA genotype of IGF-1(-2995 C/A), while younger patients more often had advanced disease and mucinous adenocarcinoma.
分析胰岛素样生长因子-1（IGF-1）-2995C/A 多态性在年轻和老年结直肠癌（CRC）患者中的分布差异。
收集了 2000 年至 2005 年在台北荣民总医院接受手术的 950 例 CRC 患者的信息。在 CRC 发病时处于年龄极端范围的患者（即分别低于第 20 百分位和高于第 80 百分位）中分析 IGF-1 多态性。分析了临床病理变量与 IGF-1 多态性之间的关系。
年轻 CRC 患者的晚期疾病（58.7%）和黏液腺癌（20%）发生率高于老年 CRC 患者。在老年 CRC 患者中，IGF-1 的 AA 基因型频率为 12.7%（24/189），明显高于年轻患者（4.2%）。其他临床病理因素，包括肿瘤位置、分化、淋巴血管侵犯和 TNM 分期与 IGF-1 的 AA 基因型无关。黏液分化（而非其他临床病理因素）与 IGF-1 的 CA/AA 基因型显著相关（39/195）。
老年患者 IGF-1（-2995C/A）的 AA 基因型频率较高，而年轻患者更常发生晚期疾病和黏液腺癌。
