State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Pediatric Surgery, Qiluhospital Shandong University, Jinan, China.
PLoS One. 2014 Feb 21;9(2):e85609. doi: 10.1371/journal.pone.0085609. eCollection 2014.
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are members of the insulin-like growth factor (IGF) family that play important roles in carcinogenesis. We hypothesized that the functional polymorphisms in IGF-I and IGFBP-3 may be associated with the risk of prostate cancer (PCa) in the Chinese population. This hospital-based case-control study included 664 PCa patients and 702 cancer-free controls. Nine SNPs in IGF-I and IGFBP-3 were genotyped using the TaqMan assay. The genetic associations between the pathogenesis and progression of PCa were assessed by logistic regression. We found that the genotype and allele frequency distribution of rs6218, rs35767 and rs5742612 were significantly different when comparing PCa cases to controls (P = 0.005, 0.005 and 0.020, respectively). In the combined analysis, individuals with 2-6 risk alleles had an elevated risk of PCa compared to those with 0-1 risk alleles. We also found that the association between the combined risk alleles and the risk of PCa appeared stronger in the following subgroups: individuals older than 71 years of age (OR = 1.41, 95%CI = 1.05-1.91, P = 0.020), nonsmokers (OR = 1.68, 95%CI = 1.21-2.32, P = 0.002), nondrinkers (OR = 1.32, 95%CI = 1.02-1.61, P = 0.002), and those with a negative family history of PCa (OR = 1.28, 95%CI = 1.02-1.71, P = 0.022). Our results indicate that the three SNPs (rs6218, rs35767 and rs5742612) and the joint genotypes with 2-6 risk alleles, may contribute to the susceptibility to PCa, but not the progression, in the Chinese population.
胰岛素样生长因子-I（IGF-I）和 IGF 结合蛋白-3（IGFBP-3）是胰岛素样生长因子（IGF）家族的成员，它们在致癌作用中发挥着重要作用。我们假设 IGF-I 和 IGFBP-3 的功能性多态性可能与中国人前列腺癌（PCa）的风险相关。这项基于医院的病例对照研究包括 664 名 PCa 患者和 702 名无癌症对照者。使用 TaqMan 测定法对 IGF-I 和 IGFBP-3 中的 9 个 SNP 进行了基因分型。通过逻辑回归评估了 PCa 发病机制和进展之间的遗传相关性。我们发现，与对照组相比，PCa 病例中 rs6218、rs35767 和 rs5742612 的基因型和等位基因频率分布差异有统计学意义（P 值分别为 0.005、0.005 和 0.020）。在联合分析中，与 0-1 个风险等位基因相比，2-6 个风险等位基因的个体患 PCa 的风险升高。我们还发现，在以下亚组中，联合风险等位基因与 PCa 风险之间的关联似乎更强：年龄大于 71 岁的个体（OR = 1.41，95%CI = 1.05-1.91，P = 0.020）、不吸烟者（OR = 1.68，95%CI = 1.21-2.32，P = 0.002）、不饮酒者（OR = 1.32，95%CI = 1.02-1.61，P = 0.002）和有 PCa 阴性家族史的个体（OR = 1.28，95%CI = 1.02-1.71，P = 0.022）。我们的结果表明，这三个 SNP（rs6218、rs35767 和 rs5742612）以及具有 2-6 个风险等位基因的联合基因型可能有助于中国人对 PCa 的易感性，但不能促进其进展。
