实验性糖尿病中肾脏血管对花生四烯酸的反应性
Renal vascular responsiveness to arachidonic acid in experimental diabetes.
作者信息
Quilley J, McGiff J C
机构信息
Dept. Pharmacology, New York Medical College, Valhalla 10595.
出版信息
Br J Pharmacol. 1990 Jun;100(2):336-40. doi: 10.1111/j.1476-5381.1990.tb15805.x.
Abstract
- Isolated perfused kidneys from diabetic rats (duration 4-6 and 20-24 weeks) were more sensitive to the vasoconstrictor effects of arachidonic acid than kidneys from age-matched control rats. Sensitivity diminished with age in both control and diabetic groups. 2. The enhanced vasoconstrictor effect of arachidonic acid in diabetic rat kidneys was associated with increased conversion to prostaglandins. 3. The renal vasoconstrictor response to arachidonic acid in both groups was reduced by thromboxane A2/prostaglandin H2 receptor antagonism but not by inhibition of thromboxane synthase. 4. Diabetic rat kidneys were also more sensitive to the vasoconstrictor effects of the endoperoxide analogue, U46619, while vasoconstrictor responses to phenylephrine were not markedly different from those of control rat kidneys. 5. In conclusion, prostaglandin endoperoxides appear to mediate arachidonic acid-induced vasoconstriction in diabetic and control rat kidneys. The enhanced renal vasoconstrictor response to arachidonic acid in diabetic rats results from increased sensitivity to endoperoxides and increased formation of endoperoxides from arachidonic acid.
摘要
- 来自糖尿病大鼠（病程4 - 6周和20 - 24周）的离体灌注肾脏对花生四烯酸的血管收缩作用比年龄匹配的对照大鼠的肾脏更敏感。在对照组和糖尿病组中，敏感性均随年龄降低。2. 糖尿病大鼠肾脏中花生四烯酸增强的血管收缩作用与向前列腺素的转化增加有关。3. 两组对花生四烯酸的肾血管收缩反应通过血栓素A2/前列腺素H2受体拮抗作用而降低，但不受血栓素合酶抑制的影响。4. 糖尿病大鼠肾脏对内过氧化物类似物U46619的血管收缩作用也更敏感，而对去氧肾上腺素的血管收缩反应与对照大鼠肾脏的反应无明显差异。5. 总之，前列腺素内过氧化物似乎介导了糖尿病和对照大鼠肾脏中花生四烯酸诱导的血管收缩。糖尿病大鼠对花生四烯酸增强的肾血管收缩反应是由于对内过氧化物的敏感性增加以及花生四烯酸向内过氧化物的形成增加。
相似文献
1
Renal vascular responsiveness to arachidonic acid in experimental diabetes.实验性糖尿病中肾脏血管对花生四烯酸的反应性
Br J Pharmacol. 1990 Jun;100(2):336-40. doi: 10.1111/j.1476-5381.1990.tb15805.x.
2
Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.内过氧化物在花生四烯酸诱导的大鼠离体灌注肾血管收缩中的作用。
Br J Pharmacol. 1989 Jan;96(1):111-6. doi: 10.1111/j.1476-5381.1989.tb11790.x.
3
Augmented potentiation of renal vasoconstrictor responses by thromboxane A2 receptor stimulation in the alloxan-diabetic rat.
J Pharm Pharmacol. 1990 Jun;42(6):423-7. doi: 10.1111/j.2042-7158.1990.tb06583.x.
4
Effects of endogenous and synthetic prostanoids, the thromboxane A2 receptor agonist U-46619 and arachidonic acid on [3H]-noradrenaline release and vascular tone in rat isolated kidney.内源性和合成类前列腺素、血栓素A2受体激动剂U-46619及花生四烯酸对大鼠离体肾脏中[3H]-去甲肾上腺素释放及血管张力的影响
Br J Pharmacol. 1989 Jul;97(3):819-28. doi: 10.1111/j.1476-5381.1989.tb12021.x.
5
A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats.豚鼠和大鼠体内前列腺素H2/血栓素A2途径参与血管内血小板聚集的比较研究。
Br J Pharmacol. 1985 Feb;84(2):425-30. doi: 10.1111/j.1476-5381.1985.tb12926.x.
6
Study of tachyphylaxis to the vasoconstrictor effect of arachidonic acid in the isolated perfused kidney of the rat.
J Pharmacol Exp Ther. 1990 Jan;252(1):241-5.
7
Endotoxin priming of thromboxane-related vasoconstrictor responses in perfused rabbit lungs.内毒素引发灌注兔肺中血栓素相关的血管收缩反应。
J Appl Physiol (1985). 1997 Jul;83(1):18-24. doi: 10.1152/jappl.1997.83.1.18.
8
Changes in reactivity towards 5-hydroxytryptamine in the renal vasculature of the diabetic spontaneously hypertensive rat.糖尿病自发性高血压大鼠肾血管对5-羟色胺反应性的变化。
J Hypertens. 1997 Jul;15(7):769-74. doi: 10.1097/00004872-199715070-00009.
9
Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2.OKY 1581对支气管收缩剂对花生四烯酸和PGH2反应的影响。
J Appl Physiol (1985). 1987 May;62(5):2066-74. doi: 10.1152/jappl.1987.62.5.2066.
10
Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney.
Hypertension. 1990 Feb;15(2 Suppl):I93-6. doi: 10.1161/01.hyp.15.2_suppl.i93.
引用本文的文献
1
Improved functional vasodilation in obese Zucker rats following exercise training.运动训练可改善肥胖 Zucker 大鼠的功能性血管舒张。
Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1090-6. doi: 10.1152/ajpheart.00233.2011. Epub 2011 Jun 17.
2
Attenuated PGI2 synthesis in obese Zucker rats.肥胖 Zucker 大鼠中前列环素（PGI2）合成减弱。
Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R715-21. doi: 10.1152/ajpregu.90330.2008. Epub 2008 Dec 31.
本文引用的文献
1
Increased platelet thromboxane synthesis in diabetes mellitus.糖尿病中血小板血栓素合成增加。
J Lab Clin Med. 1981 Jan;97(1):87-96.
2
Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats.自发性糖尿病Wistar大鼠血小板和主动脉中前列腺素合成的改变。
Biochem Med. 1980 Apr;23(2):231-5. doi: 10.1016/0006-2944(80)90076-9.
3
Impact of insulin or tolbutamide treatment on 14C-arachidonic acid conversion to prostacyclin and/or thromboxane in lungs, aortas, and platelets of streptozotocin-induced diabetic rats.胰岛素或甲苯磺丁脲治疗对链脲佐菌素诱导的糖尿病大鼠肺、主动脉和血小板中14C-花生四烯酸转化为前列环素和/或血栓素的影响。
Diabetes. 1983 Sep;32(9):846-51. doi: 10.2337/diab.32.9.846.
4
Vascular responsiveness and eicosanoid production in diabetic rats.糖尿病大鼠的血管反应性和类花生酸生成
Diabetologia. 1983 May;24(5):372-6. doi: 10.1007/BF00251827.
5
Influence of streptozotocin diabetes on myocardial lipids and prostaglandin release by the rat heart.
Biochem Med. 1983 Aug;30(1):19-33. doi: 10.1016/0006-2944(83)90004-2.
6
Arachidonic acid metabolism and urinary excretion of prostaglandins and thromboxane in rats with experimental diabetes mellitus.
J Pharmacol Exp Ther. 1985 Jul;234(1):211-6.
7
Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus.链脲佐菌素诱导的糖尿病大鼠分离出的肾小球中前列腺素生成增加。
J Clin Invest. 1985 Feb;75(2):404-12. doi: 10.1172/JCI111714.
8
Changes in cardiovascular sensitivity of alloxan-treated diabetic rats to arachidonic acid.四氧嘧啶诱导的糖尿病大鼠对花生四烯酸心血管敏感性的变化。
Br J Pharmacol. 1986 Nov;89(3):613-8. doi: 10.1111/j.1476-5381.1986.tb11163.x.
9
Renal vascular responses and eicosanoid release in diabetic rats.糖尿病大鼠的肾血管反应和类花生酸释放
Am J Physiol. 1989 Nov;257(5 Pt 2):F762-8. doi: 10.1152/ajprenal.1989.257.5.F762.
10
Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.内过氧化物在花生四烯酸诱导的大鼠离体灌注肾血管收缩中的作用。
Br J Pharmacol. 1989 Jan;96(1):111-6. doi: 10.1111/j.1476-5381.1989.tb11790.x.
Zotero 插件