通过(E)-2-炔基苯基查尔酮与 2-异氰基乙酸酯的碱促进反应高效合成四氢吲哚并[2,1-b]吡咯。
An efficient route to tetrahydroindeno[2,1-b]pyrroles via a base-promoted reaction of (E)-2-alkynylphenylchalcone with 2-isocyanoacetate.
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
Org Lett. 2011 Dec 16;13(24):6402-5. doi: 10.1021/ol202708f. Epub 2011 Nov 11.
PMID:22077280
Abstract
A base-promoted cascade reaction of (E)-2-alkynylphenylchalcone with 2-isocyanoacetate provides a novel and efficient route for the synthesis of tetrahydroindeno[2,1-b]pyrroles. The reaction proceeds smoothly in air under mild conditions with high efficiency.
摘要
(E)-2-炔基苯甲酮与 2-异氰基乙酸酯的碱促进级联反应为合成四氢茚并[2,1-b]吡咯提供了一条新颖、高效的路线。该反应在空气中、温和条件下、高效率下顺利进行。
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