Vaccines and Infectious Disease Organization/International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada.
Expert Rev Vaccines. 2011 Jan;10(1):95-107. doi: 10.1586/erv.10.154.
Adjuvants are critical components of many vaccines. The majority of existing vaccines contain a single adjuvant. Owing to their inherent limitations, no single adjuvant is capable of inducing all the protective immune responses required in the many different vaccines. Consequently, investigators are exploring the potential of using formulations with multiple adjuvants in a vaccine. An emerging paradigm is that careful selection of adjuvant combinations can result in complementary and even synergistic enhancement of immune responses to vaccines. This approach is promising and presents tremendous opportunities for vaccinologists to tailor immune responses to specific vaccines. In this article, adjuvant combinations at different stages of development will be reviewed.
佐剂是许多疫苗的关键组成部分。大多数现有的疫苗都含有单一佐剂。由于其固有局限性，没有一种佐剂能够诱导许多不同疫苗所需的所有保护性免疫反应。因此，研究人员正在探索在疫苗中使用多种佐剂配方的可能性。一个新出现的范例是，仔细选择佐剂组合可以导致对疫苗的免疫反应产生互补甚至协同增强。这种方法很有前途，为疫苗学家提供了巨大的机会，可以根据特定疫苗来定制免疫反应。本文将回顾不同开发阶段的佐剂组合。
