Fu Yu, Sun Qing-li, Han Hong-bin, Hou Chao, Zhang Jun, Kang De-xuan, Fan Dong-sheng
Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
Zhonghua Yi Xue Za Zhi. 2010 Oct 12;90(37):2629-32.
To investigate whether hyperIgEaemia is associated with Hirayama disease in China.
Serum total IgE were examined in 123 patients and 82 control subjects from 2006 to 2009 at this hospital and their correlations with clinical profiles investigated. The data were analyzed by t, Chi-square and nonparametric tests.
Past or present history of allergy/atopy was found in 14 (11.4%) patients and 11(13.4%)controls. The median value of serum total IgE were 87.97, 59.21 and 51.39 IU/ml in patients, controls and health controls respectively. There were no significant difference between the patient and control groups (Z = -0.947, P = 0.344) and the health control groups (Z = -0.914, P = 0.361). Serum IgE was elevated in 57 (43.6%) patients and 30 (36.6%) controls. HyperIgEaemia was present in 29 (23.6%) patients and 13 (15.9%) controls. There was no significant difference in the frequency of history of allergy/atopy, IgE elevation or hyperIgEaemia (P > 0.05) between cases and controls. Even after analyzing the length of duration or the severity of clinical disabilities, there was no difference neither (P > 0.05).
Whether the length of duration or the severity of clinical disabilities, the serum total IgE level has no significant difference between all groups. HyperIgEaemia is not associated with Hirayama disease.
调查中国高IgE血症是否与平山病相关。
2006年至2009年期间，对本院123例患者和82例对照者进行血清总IgE检测，并研究其与临床特征的相关性。采用t检验、卡方检验和非参数检验分析数据。
14例（11.4%）患者和11例（13.4%）对照者有既往或现患过敏/特应性疾病史。患者、对照者和健康对照者血清总IgE的中位数分别为87.97、59.21和51.39 IU/ml。患者组与对照组（Z = -0.947，P = 0.344）以及健康对照组（Z = -0.914，P = 0.361）之间无显著差异。57例（43.6%）患者和30例（36.6%）对照者血清IgE升高。29例（23.6%）患者和13例（15.9%）对照者存在高IgE血症。病例组与对照组在过敏/特应性疾病史、IgE升高或高IgE血症的频率方面无显著差异（P > 0.05）。即使分析病程长短或临床残疾严重程度，也无差异（P > 0.05）。
无论病程长短或临床残疾严重程度如何，各组之间血清总IgE水平均无显著差异。高IgE血症与平山病无关。
