青少年上肢远端肌肉萎缩（平山病）患者的血清细胞因子和趋化因子谱

Serum cytokine and chemokine profiles in patients with juvenile muscular atrophy of distal upper extremity (Hirayama disease).

作者信息

Beppu Minako, Sawai Setsu, Misawa Sonoko, Mori Masahiro, Ito Shoichi, Sogawa Kazuyuki, Nishimura Motoi, Matsushita Kazuyuki, Nomura Fumio, Kuwabara Satoshi

机构信息

Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan.

Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

出版信息

J Neuroimmunol. 2017 Jan 15;302:20-22. doi: 10.1016/j.jneuroim.2016.11.011. Epub 2016 Dec 7.

DOI:10.1016/j.jneuroim.2016.11.011

PMID:27956076

Abstract

Juvenile muscular atrophy of the distal upper extremity (Hirayama disease) is characterized by adolescent-onset muscular weakness of the distal upper limb. Several studies showed the contribution of atopic disposition and hyperIgEaemia to the disease process, but it has not been well clarified. To identify cytokine and chemokine profiles in Hirayama disease, serum samples were analyzed using multiplex magnetic bead-based assay. Eotaxin, MCP-1 and RANTES levels were significantly higher in Hirayama disease (N=11) than in normal controls (N=12). These chemokines are associated with inflammatory cell recruitment. Allergic inflammation may involve in the pathogenesis of Hirayama disease.

摘要

青少年上肢远端肌肉萎缩症（平山病）的特征是青少年期起病的上肢远端肌肉无力。多项研究表明特应性体质和高IgE血症在该病进程中起作用，但尚未完全阐明。为了确定平山病中细胞因子和趋化因子的谱型，使用基于多重磁珠的检测法对血清样本进行了分析。平山病患者（n = 11）的嗜酸性粒细胞趋化因子、单核细胞趋化蛋白-1和调节激活正常T细胞表达和分泌的趋化因子水平显著高于正常对照者（n = 12）。这些趋化因子与炎症细胞募集有关。过敏性炎症可能参与了平山病的发病机制。