糖尿病对结直肠癌患者术后预后的影响：一项 945 例患者的队列研究。
Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients.
机构信息
Department of Gastrointestinal and Colorectal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
出版信息
Chin Med J (Engl). 2010 Nov;123(21):3084-8.
BACKGROUND
Diabetes mellitus plays an important role in cancer prevalence and outcomes. The aim of this study was to evaluate the influence of DM on stages and outcomes among patients with colorectal cancer.
METHODS
The study enrolled 945 patients who were diagnosed as having colorectal carcinoma from August 1994 to December 2002. In the cohort, 26 patients were diagnosed as having DM. With a median follow-up of 45.8 months, differences in overall survival and disease-free survival between the diabetes and non-diabetes groups were analyzed.
RESULTS
Kaplan and Meier analysis showed that there were no significant differences between the two groups in overall survival rates at 3 years or 5 years. At 5 years, patients with DM, compared with patients without diabetes, experienced a significantly lower disease-free survival rate (34.2% diabetics vs. 55.1% non-diabetics; P = 0.025).
CONCLUSIONS
DM was associated with an increased risk of recurrence in patients with colorectal cancer.
背景
糖尿病在癌症的患病率和结局中起着重要作用。本研究旨在评估糖尿病对结直肠癌患者分期和结局的影响。
方法
本研究纳入了 1994 年 8 月至 2002 年 12 月期间被诊断为结直肠癌的 945 名患者。在该队列中，有 26 名患者被诊断患有糖尿病。中位随访 45.8 个月后，分析了糖尿病组和非糖尿病组之间的总生存率和无病生存率的差异。
结果
Kaplan-Meier 分析显示，两组患者在 3 年或 5 年的总生存率方面无显著差异。在 5 年时，与无糖尿病的患者相比，患有糖尿病的患者无病生存率显著降低（34.2%的糖尿病患者 vs. 55.1%的非糖尿病患者；P = 0.025）。
结论
糖尿病与结直肠癌患者的复发风险增加相关。
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