Yang Peng, Huang Fang, Shi Wei-xian, Lu Gui-lan, Tian Li-Li, Cui Shu-juan, Zhang Xin, Li Shuang, Liu Bai-wei, Deng Ying, Pang Xing-huo, Wang Quan-yi
Institute of Infectious and Endemic Diseases Control, Beijing Center for Disease Contorl and Prevention, Beijing 100013, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 May;31(5):485-8.
To investigate the immunological level against influenza A (H1N1) 2009 in Beijing and provide evidence to evaluate the developing trend of the disease.
Between Nov. 27, 2009 and Dec. 23, 2009, subjects were randomly selected from patients in hospitals (infectious and respiratory diseases related departments were excluded), volunteers in blood donation center and healthy subjects attending the physical examination center. Questionnaire survey was conducted and serum samples were collected to detect the hemagglutination-inhibition (HI) antibody against influenza A (H1N1) 2009 virus.
856 subjects participated in this survey, and 127 showed positive HI antibody to this pandemic virus. The proportions of sero-positivity among 0 - 5, 6 - 17, 18 - 55, ≥ 56 year olds were 14.5%, 19.4%, 17.4% and 8.0% respectively (P = 0.009). There was no significant difference in the sero-positivity between males and females (P = 0.693). The age-adjusted positive rate was 15.8% in the population of Beijing. By multivariate logistic regression analysis, factors as age, acute respiratory symptoms and the rate of pandemic (H1N1) 2009 vaccination were significantly associated with sero-positivity of HI antibody to the influenza A (H1N1) 2009 virus.
Above 15% of the population in Beijing showed protective antibody against influenza A (H1N1) 2009 virus, indicating the development of immunological barrier to this disease had been formed, to some extent.
调查北京地区人群针对2009年甲型H1N1流感的免疫水平，为评估该疾病的发展趋势提供依据。
2009年11月27日至2009年12月23日，从医院患者（排除感染科和呼吸科相关科室）、献血中心志愿者以及体检中心的健康体检者中随机选取研究对象。进行问卷调查并采集血清样本，检测针对2009年甲型H1N1流感病毒的血凝抑制（HI）抗体。
856名研究对象参与了本次调查，其中127人针对该大流行病毒的HI抗体呈阳性。0 - 5岁、6 - 17岁、18 - 55岁、≥56岁人群的血清阳性率分别为14.5%、19.4%、17.4%和8.0%（P = 0.009）。男性和女性的血清阳性率无显著差异（P = 0.693）。北京市人群年龄调整后的阳性率为15.8%。多因素logistic回归分析显示，年龄、急性呼吸道症状以及2009年甲型H1N1流感疫苗接种率与针对2009年甲型H1N1流感病毒的HI抗体血清阳性显著相关。
北京地区超过15%的人群对2009年甲型H1N1流感病毒具有保护性抗体，表明在一定程度上已形成针对该疾病的免疫屏障。
