Zhang Ting-rong, Zhao Tao, Xu Xin, Gu Xiao-wei, Pan Yu-kai
Department of Oncology, Jiangyin Hospital, the Affiliated Hospital of Southeast University, Jiangyin 214400, China.
Zhonghua Zhong Liu Za Zhi. 2010 Oct;32(10):791-4.
To investigate the therapeutical effect and side-effect of docetaxel combined with cisplatin (DDP) on the treatment of local advanced esophageal cancer with concomitant radiation therapy.
Ninety patients with LOCAL advanced esophageal squamous cell carcinoma were divided into two groups: (DDP + 5-Fu) group and (docetaxel + DDP) group. Chemotherapy was carried out every 4 weeks for a total of 4 courses. The radiation dose was 50.4 Gy/28FX.
The median survival time of patients in the (DDP + 5-Fu) group was 16 months and that in (docetaxel + DDP) group was 21 months (P = 0.0278). The 3-year survival rate in the (docetaxel + DDP) group was obviously higher than that in the (DDP + 5-Fu) group (23.9% vs. 12.1%). The ORR in (docetaxel + DDP) group (84.5%) was significantly higher than that in the (DDP + 5-Fu) group (71.1%) (P = 0.025). No significant differences were observed in the incidence of side-effects in the two groups.
The conventional dose chemotherapy of docetaxel + DDP with concomitant radiation therapy showed a better partial remission rate and long-term survival rate for the treatment of local advanced esophageal cancer than the traditional chemotherapy (DDP + 5-Fu) with concomitant radiation therapy and the side-effects are not increased.
探讨多西他赛联合顺铂（DDP）同步放疗治疗局部晚期食管癌的疗效及副作用。
将90例局部晚期食管鳞状细胞癌患者分为两组：（DDP + 5-Fu）组和（多西他赛 + DDP）组。每4周进行一次化疗，共4个疗程。放疗剂量为50.4 Gy/28次分割。
（DDP + 5-Fu）组患者的中位生存时间为16个月，（多西他赛 + DDP）组为21个月（P = 0.0278）。（多西他赛 + DDP）组的3年生存率明显高于（DDP + 5-Fu）组（23.9%对12.1%）。（多西他赛 + DDP）组的客观缓解率（ORR）（84.5%）显著高于（DDP + 5-Fu）组（71.1%）（P = 0.025）。两组副作用发生率无显著差异。
多西他赛 + DDP常规剂量化疗同步放疗治疗局部晚期食管癌较传统化疗（DDP + 5-Fu）同步放疗显示出更好的部分缓解率和长期生存率，且副作用未增加。
