Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
Chin Med J (Engl). 2010 Nov;123(22):3334-42.
To review the current research into Foxp3(+) regulatory T cells (Treg) cell surface molecules, plasticity of Treg cells and mechanisms of Treg cell suppression and to explore the possibilities to interfere in Treg cell suppression of anti-tumor immunity.
A literature search of all English articles was performed on the online electronic PubMed database dated 1995 to 2010. The keywords searched included: CD4(+)CD25(+)Foxp3(+) regulatory T lymphocytes, cancer, and immunotherapy. After finding relevant articles within these search limits, a manual search was conducted through the references from these articles.
Articles regarding the role of Treg cells in tumor immunity and the utility of Treg cells in tumor immunotherapy.
The results show that significant numbers of Treg cells are found in many tumors and it has been shown that the number of tumor infiltrating Treg cells correlates with adverse clinic outcomes. Treg cells are emerging as a key component of acquired tolerance to tumors.
Several mechanisms of immunosuppression can be mediated by Treg cell function. Distinct immunosuppressive molecules expressed by Treg cells or diverse molecules related to Treg induction or migration represent potential drug targets for cancer immunotherapy.
回顾 Foxp3(+) 调节性 T 细胞（Treg）细胞表面分子、Treg 细胞可塑性以及 Treg 细胞抑制机制的研究现状，探索干预 Treg 细胞抑制抗肿瘤免疫的可能性。
检索 1995 年至 2010 年在线电子 PubMed 数据库中所有英文文献，检索词包括 CD4(+)CD25(+)Foxp3(+) 调节性 T 淋巴细胞、癌症和免疫治疗。在这些搜索限制内找到相关文章后，通过这些文章的参考文献进行手动搜索。
关于 Treg 细胞在肿瘤免疫中的作用以及 Treg 细胞在肿瘤免疫治疗中的应用的文章。
结果表明，许多肿瘤中存在大量的 Treg 细胞，并且已经证明肿瘤浸润性 Treg 细胞的数量与不良临床结局相关。Treg 细胞正在成为获得性对肿瘤耐受的关键组成部分。
Treg 细胞功能可以介导几种免疫抑制机制。Treg 细胞表达的独特免疫抑制分子或与 Treg 诱导或迁移相关的不同分子代表癌症免疫治疗的潜在药物靶点。
