Department of Pharmacology, University of Pennsylvania, Institute for Translational Medicine and Therapeutics, Philadelphia, PA, USA.
Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):14-20. doi: 10.1016/j.prostaglandins.2011.08.005. Epub 2011 Aug 31.
COX-derived prostanoids play multiple roles in inflammation and cancer. This review highlights research examining COX-2 and PGE(2)-dependent regulation of immune cell polarization and function within the tumor microenvironment, particularly as it pertains to breast cancer. Appreciating PGE(2)-mediated immunomodulation is important in understanding how tumors evade immune surveillance by re-educating infiltrating inflammatory and immune cells to support tumorigenesis. Elucidation of the multiple and complex influences exerted by tumor stromal components may lead to targeted therapies in breast and other cancers that restrain microenvironmental permissiveness and maintain natural defenses against malignancies.
COX 衍生的前列腺素在炎症和癌症中发挥多种作用。本综述重点介绍了研究 COX-2 和 PGE（2）依赖性调节肿瘤微环境中免疫细胞极化和功能的研究，特别是与乳腺癌有关的研究。了解 PGE（2）介导的免疫调节对于理解肿瘤如何通过重新教育浸润性炎症和免疫细胞来支持肿瘤发生从而逃避免疫监视非常重要。阐明肿瘤基质成分施加的多种复杂影响可能会导致针对乳腺癌和其他癌症的靶向治疗，这些治疗可以限制微环境的许可并维持对恶性肿瘤的天然防御。
