Newlove Tracey, Loyd Aaron, Patel Rishi, Jelinek Josef, Latkowski Jo-Ann
Department of Dermatology, New York University, New York, NY, USA.
Dermatol Online J. 2010 Nov 15;16(11):2.
Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary or localized nodules or plaques. Histopathologic features include a diffuse, non-epidermotropic infiltrate with cohesive sheets of large anaplastic CD30+ tumor cells. This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis. Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease.
原发性皮肤间变性大细胞淋巴瘤（ALCL）是皮肤T细胞淋巴瘤的一种形式，其特征为孤立性或局限性结节或斑块。组织病理学特征包括弥漫性、非亲表皮性浸润，伴有大的间变性CD30+肿瘤细胞的黏附性片层。该实体必须与伴有皮肤受累的系统性ALCL和淋巴瘤样丘疹病相鉴别。治疗方式包括临床监测、放射治疗和手术切除，系统性化疗仅用于播散性或皮肤外疾病。
