Lu Phoebe D, Ralston Jonathan, Kamino Hideko, Stein Jennifer A
Department of Dermatology, New York University, New York, NY, USA.
Dermatol Online J. 2010 Nov 15;16(11):10.
Pemphigoid gestationis is a rare autoimmune blistering disease of pregnancy. It is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions. Pemphigoid gestationis has been associated with premature delivery, small-for-gestational-age infants. Recurrences with subsequent pregnancies are often more severe. Oral glucocorticoids are the mainstay of therapy. Differentiation of pemphigoid gestationis from pruritic urticarial papules and plaques of pregnancy is essential because management and outcomes differ. In instances in which clinical diagnosis is difficult, direct immunofluorescence tests, immunoblots, or ELISA studies of anti-basement-membrane zone antibodies are useful in establishing the diagnosis.
妊娠类天疱疮是一种罕见的妊娠期间发生的自身免疫性水疱病。其特征为瘙痒性荨麻疹样斑块，病变内出现紧张性水疱和大疱。妊娠类天疱疮与早产、小于胎龄儿有关。后续妊娠复发时病情往往更严重。口服糖皮质激素是主要治疗方法。区分妊娠类天疱疮与妊娠瘙痒性荨疹性丘疹和斑块至关重要，因为管理和预后有所不同。在临床诊断困难的情况下，直接免疫荧光试验、免疫印迹或抗基底膜带抗体的ELISA研究有助于确诊。
