患者血浆 nesfatin-1 水平升高与重度抑郁症。
High plasma nesfatin-1 level in patients with major depressive disorder.
机构信息
Mustafa Kemal University Medical Faculty, Department of Psychiatry, Antakya, Turkey.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):497-500. doi: 10.1016/j.pnpbp.2010.12.004. Epub 2010 Dec 14.
AIM
In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group.
METHOD
Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels.
RESULTS
The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r=0.59, p<0.001) and in the control group (r=0.58, p<0.001).
CONCLUSION
Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level.
目的
本研究旨在检测新发现的肽类激素 nesfatin-1 在重度抑郁症患者血浆中的浓度变化，并与对照组进行比较。
方法
从默罕默德·凯末尔大学医学院研究与培训医院精神科门诊中随机选取患者组，从健康志愿者中选取对照组。健康对照组在体重和体重指数方面与患者组相匹配。两组均采用汉密尔顿抑郁量表（HAM-D）进行评分。采用 ELISA 法检测血浆 nesfatin-1 水平。
结果
与对照组相比，重度抑郁症患者的平均 nesfatin-1 水平显著升高（p<0.001）。患者组（r=0.59，p<0.001）和对照组（r=0.58，p<0.001）的血浆 nesfatin-1 水平与 HAM-D 评分均呈正相关。
结论
我们的研究结果提示，重度抑郁症与血浆 nesfatin-1 水平升高之间可能存在一定的关系。
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