Department of Psychology, University of New Orleans, New Orleans, LA 70148, USA.
Neurosci Lett. 2011 Feb 11;489(3):182-6. doi: 10.1016/j.neulet.2010.12.012. Epub 2010 Dec 14.
Rhes, the Ras Homolog Enriched in Striatum, is an intermediate-size GTP binding protein. Although its full functions are not yet known, it has been shown to affect signaling and behaviors mediated by G protein-coupled receptors. Here we have tested whether Rhes affects behaviors mediated by opioid receptors. Wild type and rhes-deficient mice were administered morphine and tested for analgesia in formalin and tail flick tests. Rhes⁻/⁻ mice showed significantly enhanced analgesia in both tests relative to rhes+/+ mice. Furthermore, rhes⁻/⁻ mice did not display tolerance to repeated morphine administration and displayed significantly less withdrawal than rhes+/+ mice. These findings indicate that Rhes is involved in behaviors mediated by mu opioid receptors and in the adaptive response to repeated morphine administration.
Rhes，富含纹状体的 Ras 同源物，是一种中等大小的 GTP 结合蛋白。尽管其全部功能尚不清楚，但已表明它会影响由 G 蛋白偶联受体介导的信号转导和行为。在这里，我们测试了 Rhes 是否会影响阿片受体介导的行为。给予野生型和 rhes 缺陷型小鼠吗啡，并在福尔马林和尾部闪烁试验中测试其镇痛作用。与 rhes+/+ 小鼠相比，rhes⁻/⁻ 小鼠在这两种测试中均表现出明显更强的镇痛作用。此外，rhes⁻/⁻ 小鼠对重复吗啡给药没有产生耐受性，并且与 rhes+/+ 小鼠相比，其戒断症状明显减少。这些发现表明，Rhes 参与了μ阿片受体介导的行为以及对重复吗啡给药的适应性反应。
