通过层层组装制备刺激响应性多层壳聚糖中空微球。
Stimuli-responsive multilayer chitosan hollow microspheres via layer-by-layer assembly.
机构信息
State Key Laboratory of Applied Organic Chemistry, and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
出版信息
Colloids Surf B Biointerfaces. 2011 Apr 1;83(2):254-9. doi: 10.1016/j.colsurfb.2010.11.029. Epub 2010 Nov 27.
Novel stimuli-responsive multilayer chitosan hollow microspheres with chitosan as the unique component have been fabricated by the sequential layer-by-layer electrostatic assembly technique from the sacrificial templates (polystyrene sulfonate, PSS) with chitosan (CS) as the polycation and carboxymethyl chitosan (CMCS) as the polyanion, respectively. Their hollow structure was confirmed by the TEM analysis. The DLS analysis indicated that the multilayer chitosan microcapsules were pH and ionic strength dual-responsive. Due to the biocompatibility of the single component chitosan used, the multilayer chitosan microcapsules are expected to be used in the controlled release of drugs.
新型刺激响应性壳聚糖中空微球具有壳聚糖作为独特的成分，由牺牲模板（聚苯乙烯磺酸钠，PSS）与壳聚糖（CS）作为聚阳离子和羧甲基壳聚糖（CMCS）作为聚阴离子，分别通过顺序层层静电组装技术制备而成。TEM 分析证实了它们的中空结构。DLS 分析表明，多层壳聚糖微胶囊对 pH 和离子强度具有双重响应。由于使用的单一成分壳聚糖的生物相容性，预计多层壳聚糖微胶囊将用于药物的控制释放。
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