State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):385-90. doi: 10.1016/j.colsurfb.2010.09.024. Epub 2010 Nov 11.
The disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules have been fabricated via the covalent layer-by-layer assembly between the amino groups of chitosan (CS) and the aldehyde groups of the oxidized sodium alginate (OSA) onto the sacrificial templates (polystyrene sulfonate, PSS) which was removed by dialysis subsequently. The covalent crosslinking bonds of the multilayer microcapsules were confirmed by FTIR analysis. The TEM analysis showed that the diameter of the multilayer microcapsules was <200nm. The diameter of the multilayer microcapsules decreased with the increasing of the pH values or the ionic strength. The pH and ionic strength dual-responsive multilayer microcapsules were stable in acidic and neutral media while they could disintegrate only at strong basic media.
通过壳聚糖（CS）上的氨基与氧化的海藻酸钠（OSA）上的醛基之间的共价逐层组装，在牺牲模板（聚苯乙烯磺酸钠，PSS）上制备了可控制解聚的刺激响应性聚电解质多层微胶囊，随后通过透析将其去除。通过 FTIR 分析证实了多层微胶囊的共价交联键。TEM 分析表明，多层微胶囊的直径<200nm。随着 pH 值或离子强度的增加，多层微胶囊的直径减小。pH 和离子强度双重响应的多层微胶囊在酸性和中性介质中稳定，而仅在强碱性介质中才会分解。
