Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Cytokine. 2011 Mar;53(3):271-81. doi: 10.1016/j.cyto.2010.11.013. Epub 2010 Dec 16.
Gene expression is regulated by the combined action of transcriptional activators and transcriptional repressors. Transcriptional repressors function by recruiting corepressor complexes containing histone-modifying enzymes to specific sites within DNA. Chromatin modifying complexes are subsequently recruited, either directly by transcriptional repressors, or indirectly via corepressor complexes and/or histone modifications, to remodel chromatin into either a transcription-friendly 'open' form or an inhibitory 'closed' form. Transcriptional repressors, corepressors and chromatin modifying complexes play critical roles throughout T cell development. Here, we highlight those genes that function to repress transcription and that have been shown to be required for T cell development.
基因表达受转录激活因子和转录阻遏因子的共同作用调控。转录阻遏因子通过募集包含组蛋白修饰酶的共抑制复合物到 DNA 中的特定位点起作用。随后，染色质修饰复合物被募集，或者直接由转录阻遏因子募集，或者间接通过共抑制复合物和/或组蛋白修饰募集，以将染色质重塑为转录友好的“开放”形式或抑制性的“关闭”形式。转录阻遏因子、共抑制因子和染色质修饰复合物在 T 细胞发育过程中发挥关键作用。在这里，我们重点介绍那些具有转录抑制功能并已被证明是 T 细胞发育所必需的基因。
