University of Schleswig-Holstein, Lübeck Campus, Department of Surgery, Lübeck, Germany.
Eur J Med Res. 2010 Nov 30;15(12):544-53. doi: 10.1186/2047-783x-15-12-544.
Tissue infections or skin, skin structure, and deep seated soft tissue infections are general terms for infections of the entire skin layer including the subcutaneous and muscle tissue layers and their respective fascia structures. Infections of the different mediastinal fascias (mediastinitis) and retroperitoneal fascia infections also belong to this category. Due to the variability of their clinical presentation, skin and soft tissue infections can be classified according to different features. The following aspects can be used for classification: - anatomical structures, - pathogens, - necessity for urgent treatment, - extent of infection. - The incidence of skin and soft tissue infections in which MRSA (methicillin-resistent Staphylococcus aureus) is involved has been steadily increasing over the past 15 years. These wounds should be treated according to the same open treatment principles as other infected wounds. Since these infections are often superficial contaminations, antibiotic therapy is not indicated. If systemic infection occurs in form of MRSA sepsis, antibiotic therapy is indicated. - Several recent reports identified MRSA as the leading pathogen in SSTIs. It also causes 20% to 50% of diabetes-associated foot infections in several countries and is associated with worse outcomes than other pathogens.
组织感染或皮肤、皮肤结构和深部软组织感染是整个皮肤层包括皮下和肌肉组织层及其各自的筋膜结构感染的统称。不同纵隔筋膜（纵隔炎）和腹膜后筋膜感染也属于这一类。由于其临床表现的多样性，皮肤和软组织感染可以根据不同的特征进行分类。以下方面可用于分类：-解剖结构，-病原体，-紧急治疗的必要性，-感染程度。-在过去 15 年中，涉及耐甲氧西林金黄色葡萄球菌（MRSA）的皮肤和软组织感染的发病率一直在稳步上升。这些伤口应按照与其他感染性伤口相同的开放性治疗原则进行治疗。由于这些感染通常是浅表污染，因此不需要抗生素治疗。如果出现全身性感染，如 MRSA 败血症，则需要抗生素治疗。-最近的几份报告确定 MRSA 是 SSTIs 的主要病原体。它还导致几个国家 20%至 50%的糖尿病相关足部感染，并且与其他病原体相比，其结果更差。
