高IgE综合征患者中IgE和IgG4合成的调节
Regulation of IgE and IgG4 synthesis in patients with hyper IgE syndrome.
作者信息
Ishizaka A, Joh K, Shibata R, Wagatsuma Y, Nakanishi M, Tomizawa K, Kojima K, Kandil E, Sakiyama Y, Matsumoto S
机构信息
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
出版信息
Immunology. 1990 Jul;70(3):414-6.
In order to investigate the imbalance of IgG subclasses and its relationship to IgE level, 14 patients with hyper IgE syndrome (HIE syndrome) were examined for serum IgG subclasses and IgE levels and five of these patients were studied for in vitro IgE and IgG subclass production by peripheral blood lymphocytes (PBL) in response to interleukin-4 (IL-4)/interferon-gamma (IFN-gamma). Serum IgE levels were highly correlative with serum IgG4 levels (r = 0.75, P less than 0.005), but not with IgG1, IgG2 or IgG3 levels (r = 0.21, 0.43 and 0.41, respectively). In an in vitro study, recombinant IL-4 enhanced not only spontaneous IgE synthesis but also IgG4 synthesis in cultures of PBL from patients with HIE syndrome as well as in healthy donors (P less than 0.01), and the effect of recombinant IL-4 on both IgE and IgG4 synthesis was inhibited by low concentrations of recombinant IFN-gamma (P less than 0.01). The disturbed regulation of IgE and IgG4 seen in patients with hyper IgE syndrome may be caused mainly by the disturbed regulation of both cytokines.
为了研究IgG亚类的失衡及其与IgE水平的关系，对14例高IgE综合征（HIE综合征）患者进行了血清IgG亚类和IgE水平检测，并对其中5例患者的外周血淋巴细胞（PBL）在白细胞介素-4（IL-4）/干扰素-γ（IFN-γ）刺激下体外产生IgE和IgG亚类的情况进行了研究。血清IgE水平与血清IgG4水平高度相关（r = 0.75，P < 0.005），但与IgG1、IgG2或IgG3水平无关（r分别为0.21、0.43和0.41）。在一项体外研究中，重组IL-4不仅增强了HIE综合征患者以及健康供体PBL培养物中的自发IgE合成，还增强了IgG4合成（P < 0.01），低浓度的重组IFN-γ抑制了重组IL-4对IgE和IgG4合成的作用（P < 0.01）。高IgE综合征患者中所见的IgE和IgG4调节紊乱可能主要由两种细胞因子的调节紊乱引起。
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