Cosmetic Ingredient Review, Washington, DC 20036, USA.
Int J Toxicol. 2010 Nov-Dec;29(6 Suppl):221S-43. doi: 10.1177/1091581810384883.
Calendula officinalis extract, C officinalis flower, C officinalis flower extract, C officinalis flower oil, and C officinalis seed oil are cosmetic ingredients derived from C officinalis. These ingredients may contain minerals, carbohydrates, lipids, phenolic acids, flavonoids, tannins, coumarins, sterols and steroids, monoterpenes, sesquiterpenes, triterpenes, tocopherols, quinones, amino acids, and resins. These ingredients were not significantly toxic in single-dose oral studies using animals. The absence of reproductive/developmental toxicity was inferred from repeat-dose studies of coriander oil, with a similar composition. Overall, these ingredients were not genotoxic. They also were not irritating, sensitizing, or photosensitizing in animal or clinical tests but may be mild ocular irritants. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that these ingredients are safe for use in cosmetics in the practices of use and concentration given in this amended safety assessment.
金盏花提取物、金盏花花、金盏花花提取物、金盏花花油和金盏金花籽油是源自金盏花的化妆品成分。这些成分可能含有矿物质、碳水化合物、脂类、酚酸、类黄酮、单宁、香豆素、甾醇和类固醇、单萜、倍半萜、三萜、生育酚、醌、氨基酸和树脂。这些成分在动物单次口服研究中没有明显毒性。香菜油的重复剂量研究推断其没有生殖/发育毒性，其组成相似。总体而言，这些成分没有遗传毒性。在动物或临床测试中，它们也没有刺激性、致敏性或光致敏性，但可能对眼睛有轻微刺激性。化妆品成分评估专家小组（CIR）得出结论，这些成分在本次修订的安全性评估中给出的使用方法和浓度下，在化妆品中使用是安全的。
