Cosmetic Ingredient Review, Washington, DC 20036, USA.
Int J Toxicol. 2010 Nov-Dec;29(6 Suppl):288S-305. doi: 10.1177/1091581810386124.
Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not toxic in single-dose oral and dermal animal tests, and no systemic toxicities were observed in repeat-dose dermal animal studies. In dermal animal studies, no evidence of reproductive or developmental toxicity was reported. At 15% concentrations, sodium dodecylbenzenesulfonate was severely irritating to rabbit skin. The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Products containing these ingredients should be formulated to ensure that the irritancy potential is minimized.
十二烷基苯磺酸钠是烷基苯磺酸盐中的一组盐，用于化妆品中作为表面活性剂清洁剂。十二烷基苯磺酸钠可溶于水，部分溶于乙醇，其经皮吸收取决于 pH 值。在单次口服和经皮的动物试验中，十二烷基苯磺酸盐盐并无毒性，在重复经皮的动物研究中也未观察到全身毒性。在经皮的动物研究中，未报告这些成分具有生殖或发育毒性的证据。在 15%的浓度下，十二烷基苯磺酸钠对兔皮肤有严重的刺激性。化妆品成分评估专家小组得出结论，这些成分的刺激性与其他清洁剂相似，其严重程度取决于浓度和 pH 值。含有这些成分的产品应进行配方设计，以确保将刺激性的潜在风险最小化。
