Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands.
Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):672-7. doi: 10.1161/ATVBAHA.110.209569. Epub 2010 Dec 16.
Several acquired risk factors for venous thrombosis (VT) are associated with high prolactin levels. Our goal was to investigate VT risk for different levels of prolactin.
We used data of a case-control study on leg vein thrombosis conducted between September 1999 and August 2006 at the Academic Medical Center, Amsterdam, the Netherlands. Prolactin was assessed in 187 cases (mean age, 57 years; range, 19 to 90) and 374 gender-matched controls (mean age, 57 years; range, 18 to 93). Odds ratios and 95% CI for VT risk were estimated based on several cutoff levels derived from prolactin levels in controls. Odds ratios for VT risk clearly increased with higher prolactin levels. For prolactin levels above the 75th percentile (8 μg/L), we found an odds ratio of 1.7 (95% CI 1.0 to 2.7) as compared with levels below the 50th percentile (6 μg/L). This further increased up to an odds ratio of 4.7 (95% CI 1.8 to 11.8) for prolactin levels above the 97.5th percentile (16 μg/L). The risk was most pronounced in premenopausal women.
Our data suggest that prolactin levels are associated with VT in a dose-dependent fashion. Future studies are needed to evaluate the causality of this relationship.
一些获得性静脉血栓形成（VT）风险因素与高催乳素水平有关。我们的目标是研究不同催乳素水平的 VT 风险。
我们使用了荷兰阿姆斯特丹学术医学中心于 1999 年 9 月至 2006 年 8 月进行的静脉血栓栓塞症病例对照研究的数据。187 例病例（平均年龄 57 岁；范围 19 至 90 岁）和 374 例性别匹配的对照组（平均年龄 57 岁；范围 18 至 93 岁）均进行了催乳素评估。基于对照组中催乳素水平得出的几个截定点，估计了 VT 风险的比值比和 95%CI。随着催乳素水平的升高，VT 风险的比值比明显增加。对于催乳素水平高于第 75 百分位（8μg/L），我们发现与第 50 百分位（6μg/L）以下的水平相比，比值比为 1.7（95%CI 1.0 至 2.7）。这一比值进一步上升至第 97.5 百分位（16μg/L）以上时，比值比为 4.7（95%CI 1.8 至 11.8）。这种风险在绝经前妇女中最为明显。
我们的数据表明，催乳素水平与 VT 呈剂量依赖性相关。需要进一步的研究来评估这种关系的因果关系。
