Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Front Endocrinol (Lausanne). 2021 Feb 25;12:571229. doi: 10.3389/fendo.2021.571229. eCollection 2021.
Our study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS).
This was a retrospective cross-sectional study performed in the reproductive medicine center of the first affiliated hospital of Wenzhou Medical University. From January 2007 to August 2018, a total of 792 PCOS and 700 non-PCOS infertile women were included. All patients' prolactin levels were in the normal range. PCOS was diagnosed according to the Rotterdam Criteria. Anthropometric parameters, blood pressure, serum prolactin levels, sex hormones, fasting lipids, fasting plasma glucose (FPG), fasting insulin (FINS) and hepatic biological parameters were measured in all subjects.
Serum prolactin levels in PCOS women were significantly decreased compared with levels in non-PCOS women after adjusting for age and BMI ( < 0.05). Moreover, we found that prolactin levels were positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with age, BMI, waist circumference (WC), hip circumference (HC), luteinizing hormone/follicle stimulating hormone (LH/FSH), estradiol (E), FINS, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β (HOMA-β), triglyceride (TG) and alanine aminotransferase (ALT) ( < 0.05). After adjusting for age and BMI, multiple linear regression analysis revealed that LH, LH/FSH, E, FINS, HOMA-IR, and HOMA-β were negatively associated with serum PRL ( < 0.05).
Low serum PRL levels within the normal range associates with a higher incidence of insulin resistance and beta-cell dysfunction in infertile women with PCOS.
本研究旨在探讨血清催乳素（PRL）水平与多囊卵巢综合征（PCOS）不孕患者胰岛素抵抗和β细胞功能障碍的关系。
这是一项在温州医科大学附属第一医院生殖医学中心进行的回顾性横断面研究。2007 年 1 月至 2018 年 8 月，共纳入 792 例 PCOS 不孕患者和 700 例非 PCOS 不孕患者。所有患者的催乳素水平均在正常范围内。根据 Rotterdam 标准诊断 PCOS。所有患者均测量了人体测量参数、血压、血清催乳素水平、性激素、空腹血脂、空腹血糖（FPG）、空腹胰岛素（FINS）和肝生物参数。
调整年龄和 BMI 后，PCOS 妇女的血清催乳素水平明显低于非 PCOS 妇女（<0.05）。此外，我们发现催乳素水平与高密度脂蛋白胆固醇（HDL-C）呈正相关，与年龄、BMI、腰围（WC）、臀围（HC）、促黄体生成素/卵泡刺激素（LH/FSH）、雌二醇（E）、FINS、胰岛素抵抗评估的稳态模型（HOMA-IR）、β细胞功能评估的稳态模型（HOMA-β）、甘油三酯（TG）和丙氨酸氨基转移酶（ALT）呈负相关（<0.05）。在调整年龄和 BMI 后，多元线性回归分析显示 LH、LH/FSH、E、FINS、HOMA-IR 和 HOMA-β 与血清 PRL 呈负相关（<0.05）。
正常范围内较低的血清 PRL 水平与 PCOS 不孕患者胰岛素抵抗和β细胞功能障碍的发生率较高有关。
