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本文引用的文献

1
Children treated with metronomic chemotherapy in a low-income country: METRO-MALI-01.在低收入国家接受节拍化疗的儿童：METRO - MALI - 01。
J Pediatr Hematol Oncol. 2011 Jan;33(1):31-4. doi: 10.1097/MPH.0b013e3182018ab8.
2
Potential relevance of bell-shaped and u-shaped dose-responses for the therapeutic targeting of angiogenesis in cancer.潜在的钟形和 U 形剂量反应与癌症中血管生成的治疗靶向相关。
Dose Response. 2010 Apr 23;8(3):253-84. doi: 10.2203/dose-response.09-049.Reynolds.
3
A phase II study of high-dose celecoxib and metronomic 'low-dose' cyclophosphamide and methotrexate in patients with relapsed and refractory lymphoma.一项关于高剂量塞来昔布与节拍性“低剂量”环磷酰胺及甲氨蝶呤用于复发难治性淋巴瘤患者的II期研究。
Hematol Oncol Stem Cell Ther. 2010;3(1):13-8. doi: 10.1016/s1658-3876(10)50051-7.
4
Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide, twice-weekly methotrexate, and daily prednisone as therapy for metastatic breast cancer using vascular endothelial growth factor and soluble vascular endothelial growth factor receptor levels as markers of response.每日达肝素和环磷酰胺、每周两次甲氨蝶呤、每日泼尼松的节拍化疗联合治疗转移性乳腺癌的 I/II 期试验，以血管内皮生长因子和可溶性血管内皮生长因子受体水平作为反应标志物。
J Clin Oncol. 2010 Feb 10;28(5):723-30. doi: 10.1200/JCO.2009.24.0143. Epub 2009 Dec 21.
5
Tumour dormancy in breast cancer: an update.乳腺癌中的肿瘤休眠：最新进展
Breast Cancer Res. 2007;9(3):208. doi: 10.1186/bcr1677.
6
In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin.长春碱和雷帕霉素对人肝细胞癌相关血管生成的体内抑制作用
Histol Histopathol. 2007 Mar;22(3):285-9. doi: 10.14670/HH-22.285.
7
Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer.曲妥珠单抗联合小剂量环磷酰胺和甲氨蝶呤治疗HER-2阳性转移性乳腺癌患者。
BMC Cancer. 2006 Sep 15;6:225. doi: 10.1186/1471-2407-6-225.
8
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients.小剂量环磷酰胺方案可选择性清除终末期癌症患者的CD4+CD25+调节性T细胞，并恢复T细胞和自然杀伤细胞的效应功能。
Cancer Immunol Immunother. 2007 May;56(5):641-8. doi: 10.1007/s00262-006-0225-8. Epub 2006 Sep 8.
9
Metronomic therapy from a pharmacologist's view.
J Pediatr Hematol Oncol. 2006 Jun;28(6):325-7. doi: 10.1097/00043426-200606000-00001.
10
Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial.阿巴西普对甲氨蝶呤抵抗的活动性类风湿关节炎患者的疗效：一项随机试验。
Ann Intern Med. 2006 Jun 20;144(12):865-76. doi: 10.7326/0003-4819-144-12-200606200-00003.

Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World?

作者信息

Klement Giannoula Lakka, Kamen Barton A

出版信息

J Pediatr Hematol Oncol. 2011 Jan;33(1):1-3. doi: 10.1097/MPH.0b013e3182024918.

DOI:10.1097/MPH.0b013e3182024918
PMID:21164359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5478384/
Abstract
摘要