Department of Pediatrics, Duke University, Durham, NC, USA.
J Perinatol. 2011 Jun;31(6):425-9. doi: 10.1038/jp.2010.142. Epub 2010 Dec 16.
The purpose of this study is to examine the results of repeat lumbar puncture in infants with initial positive cerebrospinal fluid (CSF) cultures in order to determine the clinical characteristics and outcomes of infants with repeat positive cultures.
Cohort study of infants with an initial positive CSF culture undergoing repeat lumbar puncture between 1997 and 2004 at 150 neonatal intensive care units managed by the Pediatrix Medical group. We compared the clinical outcomes of infants with repeat positive cultures and infants with repeat negative cultures.
We identified 118 infants with repeat CSF cultures. Of these, 26 infants had repeat positive cultures. A higher proportion with repeat positive cultures died compared with those with repeat negative cultures, 6/23 (26%) vs. 6/81 (7%), respectively (P=0.02).
Among infants with a positive CSF culture, a repeat positive CSF culture is common. The presence of a second positive culture is associated with increased mortality.
本研究旨在检查初始脑脊液（CSF）培养阳性的婴儿重复腰椎穿刺的结果，以确定重复培养阳性婴儿的临床特征和结局。
1997 年至 2004 年，在 150 个由 Pediatrix Medical 集团管理的新生儿重症监护病房中，对初始 CSF 培养阳性并进行重复腰椎穿刺的婴儿进行队列研究。我们比较了重复培养阳性和重复培养阴性婴儿的临床结局。
我们确定了 118 例有重复 CSF 培养的婴儿。其中，26 例婴儿有重复阳性培养。与重复阴性培养相比，重复阳性培养的婴儿死亡比例更高，分别为 6/23（26%）和 6/81（7%）（P=0.02）。
在 CSF 培养阳性的婴儿中，重复 CSF 培养阳性很常见。第二次阳性培养与死亡率增加相关。
