γ干扰素在人类急性和先天性弓形虫病中的存在情况。
Presence of gamma interferon in human acute and congenital toxoplasmosis.
作者信息
Raymond J, Poissonnier M H, Thulliez P H, Forestier F, Daffos F, Lebon P
机构信息
Service de Microbiologie, Hôpital Saint Vincent de Paul, Paris, France.
出版信息
J Clin Microbiol. 1990 Jun;28(6):1434-7. doi: 10.1128/jcm.28.6.1434-1437.1990.
The production of gamma interferon in acute acquired and congenital toxoplasmosis was studied. Gamma interferon was produced at significant titers (P less than 0.001) in the course of both congenital toxoplasmosis and acquired toxoplasmosis at an early stage of infection, when Toxoplasma gondii was multiplying. Its presence in fetal blood was correlated with the positive inoculation of fetal blood or amniotic fluid into mice (95%). The data suggest that the fetus is able to synthesize gamma interferon as early as week 21 of pregnancy. This test, easily and rapidly performed, could be included among those useful for diagnosing fetal toxoplasmic disease.
对急性获得性和先天性弓形虫病中γ干扰素的产生进行了研究。在先天性弓形虫病和获得性弓形虫病感染早期，当刚地弓形虫繁殖时，γ干扰素以显著的滴度产生（P小于0.001）。其在胎儿血液中的存在与将胎儿血液或羊水接种小鼠呈阳性相关（95%）。数据表明，胎儿早在妊娠21周就能合成γ干扰素。这项检测操作简便、迅速，可纳入有助于诊断胎儿弓形虫病的检测方法之中。
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