Centre of Chronic Immunodeficiency, Medical Centre, University Freiburg, Breisacherstrasse 117, Freiburg 79106, Germany.
EMBO Rep. 2011 Jan;12(1):71-6. doi: 10.1038/embor.2010.189. Epub 2010 Dec 17.
Group B streptococcus (GBS) is a leading cause of both neonatal sepsis and meningitis, two diseases that are characterized by inflammation. However, the manner in which GBS organisms are recognized by monocytes and macrophages is poorly understood. In this study, we report that the recognition of GBS and other Gram-positive bacteria by macrophages and monocytes relies on bacterial single-stranded RNA (ssRNA). ssRNA interacts with a signalling complex, which comprises the Toll-like receptor adaptors MyD88 and UNC-93B, but not the established MyD88-dependent ssRNA sensors. The role of ssRNA in the recognition of Gram-positive bacteria--leading to the induction of inflammatory cytokines--has potential implications for sepsis pathogenesis, diagnosis and treatment.
B 组链球菌（GBS）是导致新生儿败血症和脑膜炎的主要原因，这两种疾病的特征是炎症。然而，GBS 细菌被单核细胞和巨噬细胞识别的方式还不清楚。在这项研究中，我们报告称，巨噬细胞和单核细胞对 GBS 和其他革兰氏阳性菌的识别依赖于细菌的单链 RNA（ssRNA）。ssRNA 与信号复合物相互作用，该复合物包括 Toll 样受体接头 MyD88 和 UNC-93B，但不包括已建立的 MyD88 依赖的 ssRNA 传感器。ssRNA 在识别革兰氏阳性菌中的作用，导致炎症细胞因子的诱导，可能对败血症的发病机制、诊断和治疗有影响。
