Kolter Julia, Feuerstein Reinhild, Spoeri Evelyne, Gharun Kourosh, Elling Roland, Trieu-Cuot Patrick, Goldmann Tobias, Waskow Claudia, Chen Zhijian J, Kirschning Carsten J, Deshmukh Sachin D, Henneke Philipp
Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, 79106 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany;
Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, 79106 Freiburg, Germany;
J Immunol. 2016 Mar 15;196(6):2733-41. doi: 10.4049/jimmunol.1501014. Epub 2016 Feb 12.
Streptococci are common human colonizers with a species-specific mucocutaneous distribution. At the same time, they are among the most important and most virulent invasive bacterial pathogens. Thus, site-specific cellular innate immunity, which is predominantly executed by resident and invading myeloid cells, has to be adapted with respect to streptococcal sensing, handling, and response. In this article, we show that TLR13 is the critical mouse macrophage (MΦ) receptor in the response to group B Streptococcus, both in bone marrow-derived MΦs and in mature tissue MΦs, such as those residing in the lamina propria of the colon and the dermis, as well as in microglia. In contrast, TLR13 and its chaperone UNC-93B are dispensable for a potent cytokine response of blood monocytes to group B Streptococcus, although monocytes serve as the key progenitors of intestinal and dermal MΦs. Furthermore, a specific role for TLR13 with respect to MΦ function is supported by the response to staphylococci, where TLR13 and UNC-93B limit the cytokine response in bone marrow-derived MΦs and microglia, but not in dermal MΦs. In summary, TLR13 is a critical and site-specific receptor in the single MΦ response to β-hemolytic streptococci.
链球菌是常见的人类定植菌，具有物种特异性的黏膜皮肤分布。同时，它们也是最重要、毒性最强的侵袭性细菌病原体之一。因此，主要由驻留和侵入的髓样细胞执行的位点特异性细胞固有免疫，必须在链球菌感知、处理和反应方面进行调整。在本文中，我们表明TLR13是骨髓来源的巨噬细胞（MΦ）以及成熟组织MΦ（如结肠固有层、真皮中的MΦ以及小胶质细胞）对B族链球菌反应中的关键小鼠巨噬细胞受体。相比之下，尽管单核细胞是肠道和真皮MΦ的关键祖细胞，但TLR13及其伴侣UNC - 93B对于血液单核细胞对B族链球菌的有效细胞因子反应是可有可无的。此外，对葡萄球菌的反应支持了TLR13在MΦ功能方面的特定作用，其中TLR13和UNC - 93B限制了骨髓来源的MΦ和小胶质细胞中的细胞因子反应，但在真皮MΦ中没有。总之，TLR13是单个MΦ对β溶血性链球菌反应中的关键且位点特异性的受体。
