Maestro Laura Martinez, Rodriguez Emma Martín, Vetrone Fiorenzo, Naccache Rafik, Ramirez Hector Loro, Jaque Daniel, Capobianco John A, Solé José García
GIEL, Departamento de Física de Materiales, Universidad Autónoma de Madrid, 8049 Madrid, Spain.
Opt Express. 2010 Nov 8;18(23):23544-53. doi: 10.1364/OE.18.023544.
In this paper, we demonstrate for the first time that the new class of fluoride-based inorganic upconverting nanoparticles, NaYF4:Er3+, Yb3+, are the most efficient multiphoton excited fluorescent nanoparticles developed to date. The near-infrared-to-visible conversion efficiency of the aforementioned nanoparticles surpasses that of CdSe quantum dots and gold nanorods, which are the commercially available inorganic fluorescent nanoprobes presently used for multiphoton fluorescence bioimaging. The results presented here open new perspectives for the implementation of fluorescence tomography by multiphoton fluorescence imaging.
在本文中，我们首次证明了新型氟化物基无机上转换纳米颗粒NaYF4:Er3+、Yb3+是迄今为止开发的最有效的多光子激发荧光纳米颗粒。上述纳米颗粒的近红外到可见光的转换效率超过了CdSe量子点和金纳米棒，而CdSe量子点和金纳米棒是目前用于多光子荧光生物成像的商用无机荧光纳米探针。本文给出的结果为通过多光子荧光成像实现荧光断层扫描开辟了新的前景。
